Next-generation cancer organoids
Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …
cancer heterogeneity and its implications for personalized medicine. These advancements …
Artificial intelligence in cancer research and precision medicine
Artificial intelligence (AI) is rapidly reshaping cancer research and personalized clinical
care. Availability of high-dimensionality datasets coupled with advances in high …
care. Availability of high-dimensionality datasets coupled with advances in high …
Organoid and spheroid tumor models: techniques and applications
S Gunti, ATK Hoke, KP Vu, NR London Jr - Cancers, 2021 - mdpi.com
Simple Summary Cell cultures can be carried out in three dimensions (3D). Organoids and
spheroids are different 3D cell culture models that can be cultured with different techniques …
spheroids are different 3D cell culture models that can be cultured with different techniques …
Patient-derived xenografts undergo mouse-specific tumor evolution
Patient-derived xenografts (PDXs) have become a prominent cancer model system, as they
are presumed to faithfully represent the genomic features of primary tumors. Here we …
are presumed to faithfully represent the genomic features of primary tumors. Here we …
Nanoparticles‐induced potential toxicity on human health: applications, toxicity mechanisms, and evaluation models
L Xuan, Z Ju, M Skonieczna, PK Zhou, R Huang - MedComm, 2023 - Wiley Online Library
Nanoparticles (NPs) have become one of the most popular objects of scientific study during
the past decades. However, despite wealth of study reports, still there is a gap, particularly in …
the past decades. However, despite wealth of study reports, still there is a gap, particularly in …
[HTML][HTML] A high-resolution map of human RNA translation
Translated small open reading frames (smORFs) can have important regulatory roles and
encode microproteins, yet their genome-wide identification has been challenging. We …
encode microproteins, yet their genome-wide identification has been challenging. We …
Investigation of human trophoblast invasion in vitro
BACKGROUND In humans, inadequate trophoblast invasion into the decidua is associated
with the 'great obstetrical syndromes' which include pre-eclampsia, foetal growth restriction …
with the 'great obstetrical syndromes' which include pre-eclampsia, foetal growth restriction …
[HTML][HTML] Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
S Raghavan, PS Winter, AW Navia, HL Williams… - Cell, 2021 - cell.com
Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma
(PDAC), but our understanding of their drivers, stability, and relationship to therapeutic …
(PDAC), but our understanding of their drivers, stability, and relationship to therapeutic …
The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications
Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …
since work began exploring their supramolecular interactions with DNA. In recent years …
Organoid cultures as preclinical models of non–small cell lung cancer
R Shi, N Radulovich, C Ng, N Liu, H Notsuda… - Clinical Cancer …, 2020 - AACR
Purpose: Non–small cell lung cancer (NSCLC) is the most common cause of cancer-related
deaths worldwide. There is an unmet need to develop novel clinically relevant models of …
deaths worldwide. There is an unmet need to develop novel clinically relevant models of …