Alcohol dehydrogenases (ADHs) have become important catalysts for stereoselective
oxidation and reduction reactions of alcohols, aldehydes and ketones. The aim of this …

For almost 40 years, difluoromethylene phosphonates have proven to be versatile molecular
tools in biochemical studies owing to their close resemblance to naturally occurring …

Fluorinated alkyl iodides serve as a convenient and inexpensive source of fluoroalkyl
radicals that can readily undergo addition to the C− C unsaturated bonds of alkynes and …

The chemistry of hypervalent iodine reagents has now become quite valuable due to the
reactivity of these compounds under mild reaction conditions and their resemblance in …

Over the past two decades, the domains of both frontline synthetic organic chemistry and
process chemistry have seen an increase in crosstalk between asymmetric organic …

We elaborate a method for the generation of (2-diazo-1, 1-difluoroethyl) phosphonates from
(β-amino-α, α-difluoroethyl) phosphonates as precursors and their application as masked …

Reaction discovery and catalyst screening lie at the heart of synthetic organic chemistry.
While there are efforts at de novo catalyst design using computation/artificial intelligence, at …

The gaseous neuromodulator H2S is associated with neuronal cell death pursuant to
cerebral ischemia. As cystathionine β-synthase (CBS) is the primary mediator of H2S …

Fluoroalkyl-substituted diazo compounds belong to one of the most powerful tools in organic
synthetic chemistry and their transformations have attracted numerous attention. Since the …

An efficient palladium-catalyzed phosphonyldifluoromethylation of alkenes with
bromodifluoromethylphosophonate is described. The method provides a facile access to a …