Macrophages have important roles in immune surveillance and in the maintenance of
kidney homeostasis; their response to renal injury varies enormously depending on the …

Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to
injury in many tissues. Although the extracellular matrix deposition appears unstructured …

Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging
and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half …

Fibrosis is the common end point of chronic kidney disease. The persistent production of
inflammatory cytokines and growth factors leads to an ongoing process of extracellular …

Perivascular niches in the kidney comprise heterogeneous cell populations, including
pericytes and fibroblasts, with distinct functions. These perivascular cells have crucial roles …

Myofibroblasts are a main cell-type of collagen-producing cells during tissue fibrosis, but
their origins remains controversial. While bone marrow-derived myofibroblasts in renal …

Kidney macrophages are central in kidney disease pathogenesis and have therapeutic
potential in preventing tissue injury and fibrosis. Recent studies highlighted that kidney …

Unresolved inflammation can lead to tissue fibrosis and impaired organ function.
Macrophage–myofibroblast transition (MMT) is one newly identified mechanism by which …

Fibrosis and scar formation results from chronic progressive injury in virtually every tissue
and affects a growing number of people around the world. Myofibroblasts drive fibrosis, and …

Fibroblasts and myofibroblasts play a myriad of important roles in human tissue function,
especially in wound repair and healing. Among all cells, fibroblasts are group of cells that …