Implementation of Water‐Soluble Cyclodextrin‐Based Polymers in Biomedical Applications: How Far Are We?

M Agnes, E Pancani, M Malanga… - Macromolecular …, 2022 - Wiley Online Library
Cyclodextrin‐based polymers can be prepared starting from the naturally occurring
monomers following green and low‐cost procedures. They can be selectively derivatized …

Resveratrol delivery from implanted cyclodextrin polymers provides sustained antioxidant effect on implanted neural probes

RM Haley, ST Zuckerman, H Dakhlallah… - International journal of …, 2020 - mdpi.com
Intracortical microelectrodes are valuable tools used to study and treat neurological
diseases. Due in large part to the oxidative stress and inflammatory response occurring after …

Leveraging affinity interactions to prolong drug delivery of protein therapeutics

AB Dogan, KE Dabkowski, HA von Recum - Pharmaceutics, 2022 - mdpi.com
While peptide and protein therapeutics have made tremendous advances in clinical
treatments over the past few decades, they have been largely hindered by their ability to be …

Engineering selective molecular tethers to enhance suboptimal drug properties

A Dogan, H von Recum - Acta Biomaterialia, 2020 - Elsevier
Small-molecule drugs are utilized in a wide variety of clinical applications, however, many of
these drugs suffer from one or more suboptimal properties that can hinder its delivery or …

Cyclodextrin polymer coatings resist protein fouling, mammalian cell adhesion, and bacterial attachment

GD Learn, EJ Lai, HA von Recum - BioRxiv, 2020 - biorxiv.org
Undesired attachment of proteins, cells/bacteria, and organisms on material surfaces is
problematic in industrial and health care settings. In this study, polymer coatings are …

Affinity-based polymers provide long-term immunotherapeutic drug delivery across particle size ranges optimal for macrophage targeting

NA Rohner, LN Purdue, HA von Recum - Journal of pharmaceutical …, 2021 - Elsevier
Drug delivery to specific arms of the immune system can be technically challenging to
provide prolonged drug release while limiting off-target toxicity given the limitations of …

Injectable DNA-architected nanoraspberry depot-mediated on-demand programmable refilling and release drug delivery

RS Hsu, JH Fang, WT Shen, YC Sheu, CK Su… - Nanoscale, 2020 - pubs.rsc.org
Drug delivery depots boosting a local concentration of therapeutic agents have received
great attention in clinical applications due to their low occurrence of side effects and high …

Affinity effects on the release of non-conventional antifibrotics from polymer depots

NA Rohner, D Nguyen, HA von Recum - Pharmaceutics, 2020 - mdpi.com
For many chronic fibrotic conditions, there is a need for local, sustained antifibrotic drug
delivery. A recent trend in the pharmaceutical industry is the repurposing of approved drugs …

Regenerating Antithrombotic Surfaces through Nucleic Acid Displacement

SL McNamara, Y Brudno, AB Miller… - ACS Biomaterials …, 2020 - ACS Publications
Blood-contacting devices are commonly coated with antithrombotic agents to prevent clot
formation and to extend the lifespan of the device. However, in vivo degradation of these …

Polymer microparticles prolong delivery of the 15-PGDH inhibitor SW033291

AB Dogan, NA Rohner, JNP Smith, JA Kilgore… - Pharmaceutics, 2021 - mdpi.com
As the prevalence of age-related fibrotic diseases continues to increase, novel antifibrotic
therapies are emerging to address clinical needs. However, many novel therapeutics for …