2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on …
Abstract Aim The “2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure”
replaces the “2013 ACCF/AHA Guideline for the Management of Heart Failure” and the …
replaces the “2013 ACCF/AHA Guideline for the Management of Heart Failure” and the …
Dilated cardiomyopathy: genetic determinants and mechanisms
EM McNally, L Mestroni - Circulation research, 2017 - Am Heart Assoc
Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …
Evidence-based assessment of genes in dilated cardiomyopathy
E Jordan, L Peterson, T Ai, B Asatryan, L Bronicki… - Circulation, 2021 - Am Heart Assoc
Background: Each of the cardiomyopathies, classically categorized as hypertrophic
cardiomyopathy, dilated cardiomyopathy (DCM), and arrhythmogenic right ventricular …
cardiomyopathy, dilated cardiomyopathy (DCM), and arrhythmogenic right ventricular …
Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2021 update: a policy statement of the American College of Medical …
Disclaimer: This statement is designed primarily as an educational resource for medical
geneticists and other clinicians to help them provide quality medical services. Adherence to …
geneticists and other clinicians to help them provide quality medical services. Adherence to …
Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank
Cardiometabolic diseases are the leading cause of death worldwide. Despite a known
genetic component, our understanding of these diseases remains incomplete. Here, we …
genetic component, our understanding of these diseases remains incomplete. Here, we …
Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial
BP Halliday, R Wassall, AS Lota, Z Khalique… - The Lancet, 2019 - thelancet.com
Background Patients with dilated cardiomyopathy whose symptoms and cardiac function
have recovered often ask whether their medications can be stopped. The safety of …
have recovered often ask whether their medications can be stopped. The safety of …
[HTML][HTML] The translational landscape of the human heart
Gene expression in human tissue has primarily been studied on the transcriptional level,
largely neglecting translational regulation. Here, we analyze the translatomes of 80 human …
largely neglecting translational regulation. Here, we analyze the translatomes of 80 human …
Heart failure in cardiomyopathies: a position paper from the Heart Failure Association of the European Society of Cardiology
Cardiomyopathies are a heterogeneous group of heart muscle diseases and an important
cause of heart failure (HF). Current knowledge on incidence, pathophysiology and natural …
cause of heart failure (HF). Current knowledge on incidence, pathophysiology and natural …
Genetic architecture of acute myocarditis and the overlap with inherited cardiomyopathy
AS Lota, MR Hazebroek, P Theotokis, R Wassall… - Circulation, 2022 - Am Heart Assoc
Background: Acute myocarditis is an inflammatory condition that may herald the onset of
dilated cardiomyopathy (DCM) or arrhythmogenic cardiomyopathy (ACM). We investigated …
dilated cardiomyopathy (DCM) or arrhythmogenic cardiomyopathy (ACM). We investigated …
Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations
A Fomin, A Gärtner, L Cyganek, M Tiburcy… - Science translational …, 2021 - science.org
Heterozygous truncating variants in TTN (TTNtv), the gene coding for titin, cause dilated
cardiomyopathy (DCM), but the underlying pathomechanisms are unclear and disease …
cardiomyopathy (DCM), but the underlying pathomechanisms are unclear and disease …