The increase in global lifespan has in turn increased the prevalence of osteoarthritis which
is now the most common type of arthritis. Cartilage tissue located on articular joints erodes …

Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling
and inflammation of the synovial membrane, although the etiology and pathogenesis …

Abstract Interleukin (IL)-1, first described∼ 35 years ago as a secreted product of monocytes
and neutrophils, refers to IL-1α and IL-1β, two key cytokines in the activation of innate …

Even though osteoarthritis (OA) is mainly considered as a degradative condition of the
articular cartilage, there is increasing body of data demonstrating the involvement of all …

Osteoarthritis (OA) is a well-known disease that is part of the aging process and also one of
the most common diseases among mammals. Although this musculoskeletal disorder has …

Morphological changes observed in OA include cartilage erosion as well as a variable
degree of synovial inflammation. Current research attributes these changes to a complex …

▪ Abstract The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that
binds to IL-1 receptors but does not induce any intracellular response. Two structural …

IL-1 is an important mediator of inflammation and tissue damage in multiple organs, both in
experimental animal models of disease and in human diseases. The IL-1 family consists of …

Objective To evaluate the clinical response, safety, and tolerability of a single intraarticular
injection of anakinra in patients with symptomatic osteoarthritis (OA) of the knee. Methods …

Chondrocytes are the single cellular component of hyaline cartilage. Under physiologic
conditions, they show steady-state equilibrium between anabolic and catabolic activities that …