Acute liver failure (ALF) describes a clinical syndrome of rapid hepatocyte injury leading to
liver failure manifested by coagulopathy and encephalopathy in the absence of pre-existing …

Acute liver failure (ALF) is a dynamic clinical condition manifested by an abrupt onset of a
liver-based coagulopathy and biochemical evidence of hepatocellular injury resulting from …

Pediatric acute liver failure (PALF) is a rare, rapidly progressive clinical syndrome with
significant morbidity and mortality. The phenotype of PALF manifests as abrupt onset liver …

Background & Aims Many pediatric patients with acute liver failure (PALF) do not receive a
specific diagnosis (such as herpes simplex virus or Wilson disease or fatty acid oxidation …

Idiopathic portal hypertension (IPH) is a rare disorder characterized by clinical portal
hypertension in the absence of a recognizable cause such as cirrhosis. Laboratory tests …

There is increasing global concern of severe acute hepatitis of unknown etiology in young
children. In early 2022, our center for liver transplantation in the Netherlands treated five …

The cause of pediatric acute liver failure (PALF) is unknown in up to 40% of cases. Evidence
suggests that aberrant immune system activation may play a role. We hypothesized that …

Background & Aims In the year 2022, an outbreak of indeterminate acute hepatitis and
indeterminate paediatric acute liver failure (ID-PALF) in association with adenoviraemia in …

Objectives: In many pediatric acute liver failure (PALF) cases, a diagnosis is not identified,
and the etiology is indeterminate (IND-PALF). Our pilot study found dense CD8 T-cell …

Recently, studies on transcriptome–proteome relationships have revealed mRNA/protein
expression discordance for certain genes and speculated that protein posttranslational …