Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Diabetes mellitus (DM), is a chronic disorder characterized by impaired glucose
homeostasis that results from the loss or dysfunction of pancreatic β-cells leading to type 1 …

Preventing islet β‐cells death is crucial for treating type 2 diabetes mellitus (T2DM).
Currently, clinical drugs are being developed to improve the quality of T2DM care and self …

Metabolic dysfunction associated steatotic liver disease affects millions of people worldwide.
Progress towards a definitive cure has been incremental and limited to only lifestyle …

Following the near-total depletion of pancreatic beta-cells with streptozotocin (STZ), a partial
recovery of beta-cell mass (BCM) can occur, in part due to the alpha-to beta-cell …

Recent studies reported that pancreatic β-cells are heterogeneous in terms of their
transcriptional profiles and their abilities for insulin secretion. Sub-populations of pancreatic …

The rare SLC30A8 mutation encoding a truncating p. Arg138* variant (R138X) in zinc
transporter 8 (ZnT8) is associated with a 65% reduced risk for type 2 diabetes. To determine …

Pancreatic β-cell failure by WFS1 deficiency is manifested in individuals with wolfram
syndrome (WS). The lack of a suitable human model in WS has impeded progress in the …

The propensity to develop type 2 diabetes (T2D) is known to have both environmental and
hereditary components. In those with a genetic predisposition to T2D, it is widely believed …

iPSC-derived human β-like cells (BLC) hold promise for both therapy and disease
modelling, but their generation remains challenging and their functional analyses beyond …