CSC radioresistance: a therapeutic challenge to improve radiotherapy effectiveness in cancer

MA Olivares-Urbano, C Griñán-Lisón, JA Marchal… - Cells, 2020 - mdpi.com
Radiotherapy (RT) is a modality of oncologic treatment that can be used to treat
approximately 50% of all cancer patients either alone or in combination with other treatment …

Epigenetic modifications and head and neck cancer: implications for tumor progression and resistance to therapy

RM Castilho, CH Squarize, LO Almeida - International journal of …, 2017 - mdpi.com
Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one
of the most aggressive malignancies worldwide. Despite continuous efforts to identify …

The dual role of mesenchymal stem cells in cancer pathophysiology: pro-tumorigenic effects versus therapeutic potential

Y Slama, F Ah-Pine, M Khettab, A Arcambal… - International Journal of …, 2023 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) are multipotent cells involved in numerous
physiological events, including organogenesis, the maintenance of tissue homeostasis …

Cancer stem cells: powerful targets to improve current anticancer therapeutics

RL Bighetti-Trevisan, LO Sousa… - Stem cells …, 2019 - Wiley Online Library
A frequent observation in several malignancies is the development of resistance to therapy
that results in frequent tumor relapse and metastasis. Much of the tumor resistance …

Phytochemical constituents and antibacterial activities of 45 Malay traditional medicinal plants

I Abuga, SF Sulaiman, RA Wahab, KL Ooi… - Journal of Herbal …, 2022 - Elsevier
The phytochemical constituents of medicinal plants and their antibacterial activities are proof
of their therapeutic value in treating bacterial infections. Records of phytochemical …

[HTML][HTML] Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence

LO Almeida, DM Guimarães, MD Martins, MAT Martins… - Stem cell …, 2017 - Elsevier
Adenoid cystic carcinoma (ACC) is an uncommon malignancy of the salivary glands that is
characterized by local recurrence and distant metastasis due to its resistance to …

Targeting IκappaB kinases for cancer therapy

N Awasthee, V Rai, S Chava, P Nallasamy… - Seminars in cancer …, 2019 - Elsevier
The inhibitory kappa B kinases (IKKs) and IKK related kinases are crucial regulators of the
pro-inflammatory transcription factor, nuclear factor kappa B (NF-κB). The dysregulation in …

Cephaeline is an inductor of histone H3 acetylation and inhibitor of mucoepidermoid carcinoma cancer stem cells

LC Silva, GB Borgato, VP Wagner… - Journal of Oral …, 2022 - Wiley Online Library
Aim To evaluate the potential use of Cephaeline as a therapeutic strategy to manage
mucoepidermoid carcinomas (MEC) of the salivary glands. Material and Methods UM‐HMC …

[HTML][HTML] Repurposing NFκB and HDAC inhibitors to individually target cancer stem cells and non-cancer stem cells from mucoepidermoid carcinomas

LC Silva, GB Borgato, VP Wagner… - American journal of …, 2023 - ncbi.nlm.nih.gov
Drug resistance remains a major obstacle in the treatment of mucoepidermoid carcinomas
(MEC) leading to tumor recurrence, disease progression, and metastasis. Emerging …

Synergistic efficacy of combined EGFR and HDAC inhibitors overcomes tolerance to EGFR monotherapy in salivary mucoepidermoid carcinoma

K Parag-Sharma, J Tasoulas, AM Musicant… - Oral oncology, 2021 - Elsevier
Objectives Mucoepidermoid carcinoma (MEC) is the most common type of salivary gland
malignancy. Advanced or high-grade MECs are refractory to chemotherapy, often leading to …