DNA methylation microarrays can be employed to interrogate cell-type composition in
complex tissues. Here, we expand reference-based deconvolution of blood DNA …

We performed systematic assessment of computational deconvolution methods that play an
important role in the estimation of cell type proportions from bulk methylation data. The …

Abstract Purpose of Review This article introduces the roles of perinatal DNA methylation in
human health and disease, highlights the challenges of tissue and cellular heterogeneity to …

Background Umbilical cord blood (UCB) is commonly used in epigenome-wide association
studies of prenatal exposures. Accounting for cell type composition is critical in such studies …

Introduction The human brain comprises heterogeneous cell types whose composition can
be altered with physiological and pathological conditions. New approaches to discern the …

The majority of epigenetic epidemiology studies to date have generated genome-wide
profiles from bulk tissues (eg, whole blood) however these are vulnerable to confounding …

Background The association between SOX14 and cancer has been reported. The aim of this
study was to identify and validate the potential value of SOX14 methylation in the early …

Background Per-and polyfluoroalkyl substances (PFAS) are ubiquitous, environmentally
persistent chemicals, and prenatal exposures have been associated with adverse child …

Prenatal exposure to endocrine disrupting chemicals can interfere with development, and
has been associated with social-cognitive functioning and adverse health outcomes later in …

ABSTRACT DNA methylation (DNAm) in mammals is mostly examined within the context of
CpG dinucleotides. Non-CpG DNAm is also widespread across the human genome, but the …