Biocatalysis has revolutionized chemical synthesis, providing sustainable methods for
preparing various organic molecules. In enzyme-mediated organic synthesis, most reactions …

Biocatalysis harnesses enzymes to make valuable products. This green technology is used
in countless applications from bench scale to industrial production and allows practitioners …

Developing synthetically useful enzymatic reactions that are not known in biochemistry and
organic chemistry is an important challenge in biocatalysis. Through the synergistic merger …

Since the discovery of Hofmann–Löffler–Freytag reaction more than 130 years ago, both the
structure and reactivity of nitrogen-centred radicals have been widely studied. Nevertheless …

State-of-the-art non-natural photoenzymatic catalysis typically relies on either ultraviolet light
activation or the formation of electron donor–acceptor complexes. Inspired by nature, herein …

Strategies for achieving asymmetric catalysis with azaarenes have traditionally fallen short
of accomplishing remote stereocontrol, which would greatly enhance accessibility to distinct …

Photoenzymatic catalysts are attractive for stereoselective radical reactions because the
transformation occurs within tunable enzyme active sites. When using flavoproteins for non …

Herein we disclose a strategy to promote the hydrocarboxylation of unactivated alkenes
using photochemical activation of formate salts. We illustrate that an alternative initiation …

Controlling the enantioselectivity of hydrogen atom transfer (HAT) reactions has been a long-
standing synthetic challenge. While recent advances on photoenzymatic catalysis have …

We report a highly enantioselective radical-based hydroamination of enol esters with
sulfonamides jointly catalyzed by an Ir photocatalyst, Brønsted base, and tetrapeptide thiol …