Analysis of contact pressure in a 3D model of dual-mobility hip joint prosthesis under a gait cycle

M Tauviqirrahman, MI Ammarullah, J Jamari… - Scientific reports, 2023 - nature.com
Hip joint prostheses are used to replace hip joint function in the human body. The latest dual-
mobility hip joint prosthesis has an additional component of an outer liner that acts as a …

Exerkines and osteoarthritis

S Jia, Z Yu, L Bai - Frontiers in Physiology, 2023 - frontiersin.org
Osteoarthritis (OA) is the most prevalent chronic joint disease, with physical exercise being a
widely endorsed strategy in its management guidelines. Exerkines, defined as cytokines …

Novel fibroblast phenotypes in homeostasis and chronic inflammation: From functions to potential regulators

H Miki, MC Manresa - The Journal of Physiology, 2023 - Wiley Online Library
Fibroblasts are essential components of the stroma, sustaining a variety of tissues and being
key to the process of tissue repair after injury. Their role in tissue repair has been attributed …

Obesity defined molecular endotypes in the synovium of patients with osteoarthritis provides a rationale for therapeutic targeting of fibroblast subsets

SN Wijesinghe, A Badoume, DE Nanus… - Clinical and …, 2023 - Wiley Online Library
Background Osteoarthritis (OA), a multifaceted condition, poses a significant challenge for
the successful clinical development of therapeutics due to heterogeneity. However …

Osteoarthritic chondrocytes undergo a glycolysis-related metabolic switch upon exposure to IL-1b or TNF

A Defois, N Bon, A Charpentier, M Georget… - Cell Communication and …, 2023 - Springer
Background Osteoarthritis is an age-related disease that currently faces a lack of
symptomatic treatment. Inflammation, which is mainly sustained by pro-inflammatory …

Combined–whole blood and skin fibroblasts-transcriptomic analysis in Psoriatic Arthritis reveals molecular signatures of activity, resistance and early response to …

A Grivas, M Grigoriou, N Malissovas, G Sentis… - Frontiers in …, 2022 - frontiersin.org
Background An interplay between immune cells and resident skin and joint stromal cells is
implicated in psoriatic arthritis (PsA), yet the mechanisms remain elusive with a paucity of …

Computational investigation of various stem designs with different radial clearances in total hip arthroplasty

M Kalayarasan, J Reginald, J Valerian Corda… - Cogent …, 2023 - Taylor & Francis
Hip implants are available in various shapes and sizes. This study aims to select the better
hip implant stem design and the optimal material that can be used for the implant. For all the …

Glycolysis: an emerging regulator of osteoarthritis

D Jiang, J Guo, Y Liu, W Li, D Lu - Frontiers in Immunology, 2024 - frontiersin.org
Osteoarthritis (OA) has been a leading cause of disability in the elderly and there remains a
lack of effective therapeutic approaches as the mechanisms of pathogenesis and …

Increase in TPSB2 and TPSD1 Expression in Synovium of Hip Osteoarthritis Patients Who Are Overweight

M Tsuchiya, K Fukushima, K Takata, Y Ohashi… - International Journal of …, 2023 - mdpi.com
While research suggests that increasing body mass index (BMI) is a risk factor for hip
osteoarthritis (HOA), the mechanisms of this effect are not fully understood. Tryptases are …

Oligonucleotide therapeutics for age-related musculoskeletal disorders: Successes and challenges

TA Nicholson, M Sagmeister, SN Wijesinghe, H Farah… - Pharmaceutics, 2023 - mdpi.com
Age-related disorders of the musculoskeletal system including sarcopenia, osteoporosis and
arthritis represent some of the most common chronic conditions worldwide, for which there …