The neural crest (NC) is a multipotent and temporarily migratory cell population stemming from the dorsal neural tube during vertebrate embryogenesis. Cardiac neural crest cells …
W Feng, A Bais, H He, C Rios, S Jiang, J Xu… - Nature …, 2022 - nature.com
Heart development is a continuous process involving significant remodeling during embryogenesis and neonatal stages. To date, several groups have used single-cell …
JR Raymundo, H Zhang, G Smaldone… - The Journal of …, 2024 - Am Soc Clin Investig
Aplasia cutis congenita (ACC) is a congenital epidermal defect of the midline scalp and has been proposed to be due to a primary keratinocyte abnormality. Why it forms mainly at this …
Multi-lineage development from gastruloids is enabling unprecedented opportunities to model and study human embryonic processes and is expected to accelerate ex vivo …
T Sun, A Grassam-Rowe, Z Pu, Y Li, H Ren… - Nature …, 2023 - nature.com
The heterogeneity of functional cardiomyocytes arises during heart development, which is essential to the complex and highly coordinated cardiac physiological function. Yet the …
The molecular mechanisms that drive the acquisition of distinct neural crest cell (NCC) fates is still poorly understood. Here, we identified Prdm6 as an epigenetic modifier that …
Cardiac congenital disabilities are the most common organ malformations, but we still do not understand how they arise in the human embryo. Moreover, although cardiovascular …
S Chea, J Kreger, ME Lopez-Burks, AL MacLean… - Science …, 2024 - science.org
In animal models, Nipbl deficiency phenocopies gene expression changes and birth defects seen in Cornelia de Lange syndrome, the most common cause of which is Nipbl …
T Inubushi, Y Nakanishi, M Abe, Y Takahata… - PLoS …, 2022 - journals.plos.org
Hyaluronan (HA) is a major extracellular matrix component whose tissue levels are dynamically regulated during embryonic development. Although the synthesis of HA has …