The cervicovaginal mucus barrier

G Lacroix, V Gouyer, F Gottrand… - International Journal of …, 2020 - mdpi.com
Preterm births are a global health priority that affects 15 million babies every year worldwide.
There are no effective prognostic and therapeutic strategies relating to preterm delivery, but …

Detection of ovulation, a review of currently available methods

HW Su, YC Yi, TY Wei, TC Chang… - Bioengineering & …, 2017 - Wiley Online Library
The ability to identify the precise time of ovulation is important for women who want to plan
conception or practice contraception. Here, we review the current literature on various …

Fertility awareness-based methods for women's health and family planning

M Duane, JB Stanford, CA Porucznik, P Vigil - Frontiers in Medicine, 2022 - frontiersin.org
Background Fertility awareness-based methods (FABMs) educate about reproductive health
and enable tracking and interpretation of physical signs, such as cervical fluid secretions …

Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses

SK Lai, YY Wang, K Hida, R Cone… - Proceedings of the …, 2010 - National Acad Sciences
The mechanisms by which mucus helps prevent viruses from infecting mucosal surfaces are
not well understood. We engineered non-mucoadhesive nanoparticles of various sizes and …

Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery

LM Ensign, C Schneider, JS Suk, R Cone… - Advanced …, 2012 - Wiley Online Library
A method that could provide more uniform and longer‐lasting drug and gene delivery to
mucosal surfaces holds the potential to greatly improve the effectiveness of prophylactic and …

In vitro and ex vivo models for evaluating vaginal drug delivery systems

RL Shapiro, K DeLong, F Zulfiqar, D Carter… - Advanced drug delivery …, 2022 - Elsevier
Vaginal drug delivery systems are often preferred for treating a variety of diseases and
conditions of the female reproductive tract (FRT), as delivery can be more targeted with less …

Mucoadhesive nanoparticles may disrupt the protective human mucus barrier by altering its microstructure

YY Wang, SK Lai, C So, C Schneider, R Cone… - PloS one, 2011 - journals.plos.org
Mucus secretions typically protect exposed surfaces of the eyes and respiratory,
gastrointestinal and female reproductive tracts from foreign entities, including pathogens …

Molecular and cellular cues governing nanomaterial–mucosae interactions: from nanomedicine to nanotoxicology

J das Neves, RS Arzi, A Sosnik - Chemical Society Reviews, 2020 - pubs.rsc.org
Mucosal tissues constitute the largest interface between the body and the surrounding
environment and they regulate the access of molecules, supramolecular structures …

Mucoadhesive nanosystems for vaginal microbicide development: friend or foe?

J das Neves, M Amiji… - Wiley Interdisciplinary …, 2011 - Wiley Online Library
Topical microbicides are a promising strategy in the prevention of vaginal and rectal HIV
transmission as well as other sexually transmitted pathogens. The perspective of developing …

Globular structure of human ovulatory cervical mucus

R Brunelli, M Papi, G Arcovito, A Bompiani… - The FASEB …, 2007 - Wiley Online Library
Human cervical mucus is a heterogeneous mixture of mucin glycoproteins whose relative
concentration changes during the ovulatory phases, thereby producing different mucus …