The pyrimidine scaffold is present in many bioactive drugs; therefore, efficient synthetic
routes that provide shorter reaction times, higher yields, and site-selective reactions are …

Unsaturated polyfluoroalkyl ketones in the synthesis of nitrogen-bearing heterocycles - RSC
Advances (RSC Publishing) DOI:10.1039/C5RA23759A Royal Society of Chemistry View …

Preparation of α,β-unsaturated trifluoromethylketones and their application in the synthesis of
heterocycles Page 1 Reviews and Accounts ARKIVOC 2011 (i) 246-328 Page 246 ©ARKAT-USA …

Heterocyclization of N-(1-chloro-2,2,2-trifluoroethylidene)carbamates with β-enaminoesters—a
novel synthetic strategy to functionalized trifluoromethylated pyrimidines - ScienceDirect …

Pyrimidinone scaffolds are present in a wide array of molecules with synthetic and
pharmacological utility. The inherent properties of these compounds may be attributed to …

This study reports two strategies for preparing O-alkyl derivatives of 6-substituted-4-
(trifluoromethyl) pyrimidin-(1 H)-ones: a linear protocol of alkylation, using a CCC-building …

This review presents the recent applications of some trihalomethyl carbinols, α, α, α-
trihalogenated carbonyl compounds and trichloro (bromo) methyl-containing heterocycles …

The synthesis of a series of 14 new 1-(3-(aryl-4, 5-dihydroisoxazol-5-yl) methyl)-4-
trihalomethyl-1H-pyrimidin-2-ones from the 1, 3-dipolar cycloaddition reaction of 1-allyl-4 …

The selective N-or O-alkylation of 4-(trihalomethyl) pyrimidin-2 (1 H)-ones, using 5-bromo
enones/enaminones as alkylating agents, is reported. It was found that the selectivity toward …

A simple and regioselectively controlled method for the preparation of both 1, 4-and 1, 6-
regioisomers of 1-substituted 4 (6)-trifluoromethyl-pyrimidin-2 (1 H)-ones is described. Both …