Descending control mechanisms and chronic pain
QL Chen, MM Heinricher - Current rheumatology reports, 2019 - Springer
Abstract Purpose of Review The goal of the review was to highlight recent advances in our
understanding of descending pain-modulating systems and how these contribute to …
understanding of descending pain-modulating systems and how these contribute to …
Pain modulation and the transition from acute to chronic pain
MM Heinricher - Translational research in pain and itch, 2016 - Springer
There is now increasing evidence that pathological pain states are at least in part driven by
changes in the brain itself. Descending modulatory pathways are known to mediate top …
changes in the brain itself. Descending modulatory pathways are known to mediate top …
Stroking modulates noxious-evoked brain activity in human infants
D Gursul, S Goksan, C Hartley, GS Mellado, F Moultrie… - Current Biology, 2018 - cell.com
A subclass of C fibre sensory neurons found in hairy skin are activated by gentle touch [1]
and respond optimally to stroking at∼ 1–10 cm/s, serving a protective function by promoting …
and respond optimally to stroking at∼ 1–10 cm/s, serving a protective function by promoting …
[HTML][HTML] Nociception and the neonatal brain
Measuring brain activity in infants provides an objective surrogate approach with which to
infer pain perception following noxious events. Here we discuss different approaches which …
infer pain perception following noxious events. Here we discuss different approaches which …
Postnatal maturation of the spinal-bulbo-spinal loop: brainstem control of spinal nociception is independent of sensory input in neonatal rats
The rostroventral medial medulla (RVM) is part of a rapidly acting spino-bulbo-spinal loop
that is activated by ascending nociceptive inputs and drives descending feedback …
that is activated by ascending nociceptive inputs and drives descending feedback …
Pain Modulation and the Transition from Acute to Chronic Pain
QL Chen, MM Heinricher - Translational Research in Pain and Itch, 2024 - Springer
There is now increasing evidence that pathological pain states are at least in part driven by
changes in the brain itself. Descending modulatory pathways are known to mediate top …
changes in the brain itself. Descending modulatory pathways are known to mediate top …
Responses of neurons in rostral ventromedial medulla to nociceptive stimulation of craniofacial region and tail in rats
JS Tang, CY Chiang, JO Dostrovsky, D Yao, BJ Sessle - Brain research, 2021 - Elsevier
The rostral ventromedial medulla (RVM) plays a key role in the endogenous modulation of
nociceptive transmission in the central nervous system (CNS). The primary aim of this study …
nociceptive transmission in the central nervous system (CNS). The primary aim of this study …
Activity correlations between on-like and off-like cells of the rostral ventromedial medulla and simultaneously recorded wide-dynamic-range neurons of the spinal …
Considerable evidence supports the notion that on-and off-cells of the rostral ventromedial
medulla (RVM) facilitate and depress, respectively, spinal nociceptive transmission. This …
medulla (RVM) facilitate and depress, respectively, spinal nociceptive transmission. This …
Developmental alterations in noxious-evoked EEG activity recorded from rat primary somatosensory cortex
Primary somatosensory cortex (S1) contains a nociceptive map that localizes potential tissue
damage on the body and encodes stimulus intensity. An objective and specific biomarker of …
damage on the body and encodes stimulus intensity. An objective and specific biomarker of …
Functional relationship between brainstem putative pain-facilitating neurons and spinal nociceptfive neurons during development of inflammation in rats
The so-called on-and off-cells of the rostral ventromedial medulla (RVM) send their axons to
the spinal dorsal horn. Activation of on-cells precedes and coincides with a facilitation, and …
the spinal dorsal horn. Activation of on-cells precedes and coincides with a facilitation, and …