While γδ T cells are present virtually in all vertebrates, there is a remarkable lack of
conservation of the TRG and TRD loci underlying the generation of the γδ T cell receptor …

CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite
instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of …

Abstract γδ T cells perform heterogeneous functions in homeostasis and disease across
tissues. However, it is unclear whether these roles correspond to distinct γδ subsets or to a …

Annually influenza causes a global epidemic resulting in 290,000 to 650,000 deaths and
extracts a massive toll on healthcare and the economy. Infants and children are more …

During ontogeny, γδ T cells emerge from the thymus and directly seed peripheral tissues for
in situ immunity. However, their functional role in humans has largely been defined from …

The immune system of semi-(from≥ 105 to< 110 years old) and supercentenarians (≥ 110
years old), ie oldest centenarians, is thought to have characteristics that allow them to reach …

Preterm infants are at high risk of developing neonatal sepsis. γδ T cells are thought to be an
important set of effector cells in neonates. Here, γδ T cells were investigated in a longitudinal …

The function and phenotype of γδ T cells in the context of common variable
immunodeficiency (CVID) has not been explored. CVID is a primary immunodeficiency …

Under non-pathological conditions, human γδ T cells represent a small fraction of CD3+ T
cells in peripheral blood (1-10%). They constitute a unique subset of T lymphocytes that …

Accurately identifying γδ T cells in large single-cell RNA sequencing (scRNA-seq) datasets
without additional single-cell γδ T cell receptor sequencing (sc-γδTCR-seq) or CITE-seq …