The retinal pigment epithelium is a fundamental component of the retina that plays essential
roles in visual functions. Damage to the structure and function of the retinal pigment …

Unlike in the healthy mammalian retina, macrophages in retinal degenerative states are not
solely comprised of microglia but may include monocyte-derived recruits. Recent studies …

Mammalian photoreceptor outer segment renewal is a highly coordinated process that
hinges on timed cell signaling between photoreceptor neurons and the adjacent retinal …

Routine manipulation of the mouse genome has become a landmark in biomedical
research. Traits that are only associated with advanced developmental stages can now be …

Aqueous humor (AH) can be easily and safely used to evaluate disease-specific biomarkers
in ocular disease. The aim of this study was to identify specific proteins biomarkers in the AH …

Mutations in the Membrane-type frizzled related protein (Mfrp) gene results in an early-onset
retinal degeneration associated with retinitis pigmentosa, microphthalmia, optic disc drusen …

The retinal pigment epithelium (RPE) is a highly specialised pigmented monolayer
sandwiched between the choroid and the photoreceptors in the retina. Key functions of the …

Age-related macular degeneration (AMD), an oxidative stress-linked neurodegenerative
disease, leads to irreversible damage of the central retina and severe visual impairment …

The intestinal epithelium is the first line of defense against enteric pathogens. Removal of
infected cells by exfoliation prevents mucosal translocation and systemic infection in the …

Abstract Annexins (AnxAs) are Ca 2+/phospholipid-binding proteins extensively studied and
generally involved in several diseases. Although evidence exists regarding the distribuition …