Although the molecules and cells involved in triggering immune responses against parasitic
worms (helminths) remain enigmatic, research has continued to implicate expansions of T …

Schistosoma mansoni infection may occur either as an acute infection in individuals who
have recently visited an endemic area, with no previous contact with the parasite, or as a …

Fibrogenesis is a common feature of many diseases where there is severe insult to the liver.
The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an …

The present strong emphasis on gross organ pathology (liver, kidneys, bladder) in
schistosomiasis needs to be replaced with a more balanced view of the disease that also …

Studies in mice indicate that schistosome egg-induced granuloma formation and hepatic
fibrosis depend markedly on cytokine regulation, with interleukin 10 having a central role …

Despite the well-documented immune suppression associated with human helminth
infections, studies characterizing the immune response at the single-cell level are scanty …

The host response to infection requires an immune response to be strong enough to control
the pathogen but also restrained, to minimize immune‐mediated pathology. The conflicting …

Volunteers living in an area where schistosomiasis mansoni is endemic were subjected to
ultrasound examination and classified into groups according to the levels of fibrosis …

Background. Schistosomiasis elicits cross-regulatory immune responses, but it is unclear
how antihelminthic treatment affects this balance. This study integrates data on 13 cytokines …

Similarities in the immunobiology of different parasitic worm infections indicate that co-
evolution of humans and helminths has shaped a common anti-helminth immune response …