How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?

E Guantai, K Chibale - Malaria Journal, 2011 - Springer
Malaria continues to be an enormous global health challenge, with millions of new infections
and deaths reported annually. This is partly due to the development of resistance by the …

Assessing the potential of a genetically modified Parachlorella kessleri-I with low CO2 inducible proteins for enhanced biomass and biofuel productivity

AK Singh, P Nawkarkar, VS Bhatnagar… - Journal of …, 2024 - Elsevier
The biological process is one of the promising approaches for CO 2 capture and storage.
Recently, biological sequestration using microalgae has gained much interest due to its …

Two pronged approach for prevention and therapy of COVID-19 (Sars-CoV-2) by a multi-targeted herbal drug, a component of ayurvedic decoction

R Shukla, S Singh, A Singh, K Misra - European Journal of Integrative …, 2021 - Elsevier
Introduction SARS-CoV-2 a new virus of the zoonotic coronavirus family causes the disease
COVID-19, which has become a global pandemic. One of the ways for prevention of COVID …

Molecular modeling: Origin, fundamental concepts and applications using structure-activity relationship and quantitative structure-activity relationship

CBR Santos, CC Lobato, MAC de Sousa… - Reviews in …, 2014 - ingentaconnect.com
Molecular modeling is an important tool to aid the understanding of the fundamental
concepts of structure-activity relationships, and to elucidate the mechanism of action of …

A SAR and QSAR study of new artemisinin compounds with antimalarial activity

CBR Santos, JB Vieira, CC Lobato, LIS Hage-Melim… - Molecules, 2013 - mdpi.com
The Hartree-Fock method and the 6-31G** basis set were employed to calculate the
molecular properties of artemisinin and 20 derivatives with antimalarial activity. Maps of …

A dual target of Plasmepsin IX and X: Unveiling the atomistic superiority of a core chemical scaffold in malaria therapy

G Munsamy, C Agoni… - Journal of Cellular …, 2019 - Wiley Online Library
Plasmepsin IX and X, members of the prominent aspartic family of proteases whose function
were hitherto unknown have only recently been established as key mediators of erythrocyte …

Discovering key residues of dengue virus NS2b-NS3-protease: New binding sites for antiviral inhibitors design

D Aguilera-Pesantes, LE Robayo, PE Méndez… - Biochemical and …, 2017 - Elsevier
Abstract The NS2B-NS3 protease is essential for the Dengue Virus (DENV) replication
process. This complex constitutes a target for efficient antiviral discovery because a drug …

Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5, 6, 7, 8 tetrahydropyrido [4, 3-d] pyrimidine

D Ramírez, M Bedoya, AK Kiper, S Rinné… - International Journal of …, 2019 - mdpi.com
TASK-3 potassium (K+) channels are highly expressed in the central nervous system,
regulating the membrane potential of excitable cells. TASK-3 is involved in neurotransmitter …

Structure and sequence based functional annotation of Zika virus NS2b protein: Computational insights

D Aguilera-Pesantes, MA Méndez - Biochemical and biophysical research …, 2017 - Elsevier
While Zika virus (ZIKV) outbreaks are a growing concern for global health, a deep
understanding about the virus is lacking. Here we report a contribution to the basic science …

[HTML][HTML] In silico evaluation of anti-malarial agents from Hoslundia opposita as inhibitors of Plasmodium falciparum lactate dehydrogenase (PfLDH) enzyme

DM Shadrack, SS Nyandoro, JJE Munissi… - Computational …, 2016 - scirp.org
Malaria has continued to be a health and economic problem in Africa and the world at large.
Many anti-malarial drugs have been rendered ineffective due to the emergence of resistant …