[HTML][HTML] What role of the cGAS-STING pathway plays in chronic pain?
J Wu, X Li, X Zhang, W Wang, X You - Frontiers in Molecular …, 2022 - frontiersin.org
Chronic pain interferes with daily functioning and is frequently accompanied by depression.
Currently, traditional clinic treatments do not produce satisfactory analgesic effects and …
Currently, traditional clinic treatments do not produce satisfactory analgesic effects and …
[HTML][HTML] Mechanism and effects of STING–IFN-I pathway on nociception: A narrative review
J Yang, H Ding, B Shuai, Y Zhang… - Frontiers in Molecular …, 2023 - frontiersin.org
Since the discovery of STING in 2008, numerous studies have investigated its functions in
immunity, inflammation, and cancer. STING activates downstream molecules including IFN-I …
immunity, inflammation, and cancer. STING activates downstream molecules including IFN-I …
[HTML][HTML] Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female mice
AS Prudente, SH Lee, J Roh, DD Luckemeyer… - Brain, behavior, and …, 2024 - Elsevier
Microglia, resident immune cells in the central nervous system, play a role in
neuroinflammation and the development of neuropathic pain. We found that the stimulator of …
neuroinflammation and the development of neuropathic pain. We found that the stimulator of …
Activation of mitochondrial DNA-mediated cGAS-STING pathway contributes to chronic postsurgical pain by inducing type I interferons and A1 reactive astrocytes in …
Y Chen, Y Hu, X He, H Zang, R Sun, C Zhu… - International …, 2024 - Elsevier
Chronic postsurgical pain (CPSP) is increasingly recognized as a public health issue.
Recent studies indicated the innate immune pathway of cyclic guanosine monophosphate …
Recent studies indicated the innate immune pathway of cyclic guanosine monophosphate …
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), somatic and fatigue symptoms in cardiovascular diseases comorbid major depressive disorder (MDD): A …
JPC Chang, SS Chang, HT Chen, YC Chien… - Brain, behavior, and …, 2023 - Elsevier
Abstract Introduction Cardiovascular diseases (CVDs) and major depressive disorder (MDD)
are the two most disabling diseases. Patients with CVDs comorbid depression had somatic …
are the two most disabling diseases. Patients with CVDs comorbid depression had somatic …
[HTML][HTML] Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction
Ú Franco-Enzástiga, K Natarajan, ET David, K Patel… - Iscience, 2024 - cell.com
Type I interferons (IFNs) increase the excitability of dorsal root ganglia (DRGs) neurons via
MNK-eIF4E signaling to promote pain sensitization in mice. Activation of stimulator of …
MNK-eIF4E signaling to promote pain sensitization in mice. Activation of stimulator of …
Genetic variations of ionotropic glutamate receptor pathways on interferon-α-induced depression in patients with hepatitis C viral infection
Importance The most supportive evidence of the inflammation theory of depression is that up
to one-third of patients with Hepatitis C virus infection (HCV) develop clinical depressive …
to one-third of patients with Hepatitis C virus infection (HCV) develop clinical depressive …
Somatic symptoms in inflammation-related depression: Reply to" Letter for depression-free after interferon-α exposure indicates less incidence of depressive disorder …
Somatic symptoms in inflammation-related depression: Reply to "Letter for depression-free
after interferon-α exposure indicates less incidence of depressive disorder: A longitudinal …
after interferon-α exposure indicates less incidence of depressive disorder: A longitudinal …