The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …

The kidney is innervated with efferent sympathetic nerve fibers that directly contact the
vasculature, the renal tubules, and the juxtaglomerular granular cells. Via specific …

The protease renin is the key enzyme of the renin-angiotensin-aldosterone cascade, which
is relevant under both physiological and pathophysiological settings. The kidney is the only …

Renin is a central hormone in the control of blood pressure and various other physiological
functions. In spite of the very early discovery of renin over 100 years ago, we have only …

The development of renovascular hypertension depends on the release of renin from the
juxtaglomerular (JG) cells, a process regulated by intracellular cAMP. Hydrogen sulfide (H 2 …

The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone
system, which is critically involved in salt, volume, and blood pressure homeostasis of the …

Since the advent of insulin, the improvements in diabetes detection and the therapies to treat
hyperglycemia have reduced the mortality of acute metabolic emergencies, such that today …

In the adult organism, systemically circulating renin almost exclusively originates from the
juxtaglomerular cells in the afferent arterioles of the kidneys. These cells share similarities …

The aspartyl protease renin is the rate limiting activity of the renin–angiotensin–aldosterone
system (RAAS). Renin is synthesized as an enzymatically inactive proenzyme which is …

Background: Phosphodiesterase 3A (PDE3A) gain-of-function mutations cause
hypertension with brachydactyly (HTNB) and lead to stroke. Increased peripheral vascular …