The CodY pleiotropic repressor controls virulence in gram-positive pathogens

L Stenz, P Francois, K Whiteson, C Wolz… - FEMS Immunology & …, 2011 - academic.oup.com
CodY is involved in the adaptive response to starvation in at least 30 different low G+ C
gram-positive bacteria. After dimerization and activation by cofactor binding, CodY binds to a …

Dual-site phosphorylation of the control of virulence regulator impacts group a streptococcal global gene expression and pathogenesis

N Horstmann, M Saldaña, P Sahasrabhojane… - PLoS …, 2014 - journals.plos.org
Phosphorylation relays are a major mechanism by which bacteria alter transcription in
response to environmental signals, but understanding of the functional consequences of …

RivR and the small RNA RivX: the missing links between the CovR regulatory cascade and the Mga regulon

SA Roberts, JR Scott - Molecular microbiology, 2007 - Wiley Online Library
The CovR/S two‐component system regulates the transcription of many genes that are
crucial for the virulence of Streptococcus pyogenes (group A Streptococcus, GAS) …

CovS inactivation reduces CovR promoter binding at diverse virulence factor encoding genes in group A Streptococcus

N Horstmann, KS Myers, CN Tran, AR Flores… - PLoS …, 2022 - journals.plos.org
The c ontrol ofv irulence gene r egulator (CovR), also called c aspsule s ynthesis r egulator
(CsrR), is critical to how the major human pathogen group A Streptococcus fine-tunes …

Regulation of gbpC Expression in Streptococcus mutans

I Biswas, L Drake, S Biswas - Journal of bacteriology, 2007 - Am Soc Microbiol
Streptococcus mutans, the principal causative agent of dental caries, produces four glucan-
binding proteins (Gbp) that play major roles in bacterial adherence and pathogenesis. One …

CovR-Controlled Global Regulation of Gene Expression in Streptococcus mutans

A Dmitriev, SS Mohapatra, P Chong, M Neely… - PloS one, 2011 - journals.plos.org
CovR/S is a two-component signal transduction system (TCS) that controls the expression of
various virulence related genes in many streptococci. However, in the dental pathogen …

Serine/threonine protein kinase Stk is required for virulence, stress response, and penicillin tolerance in Streptococcus pyogenes

J Bugrysheva, BJ Froehlich, JA Freiberg… - Infection and …, 2011 - Am Soc Microbiol
Genes encoding one or more Ser/Thr protein kinases have been identified recently in many
bacteria, including one (stk) in the human pathogen Streptococcus pyogenes (group A …

Characterization of Streptococcus thermophilus two-component systems: in silico analysis, functional analysis and expression of response regulator genes in pure or …

B Thevenard, N Rasoava, P Fourcassié… - International Journal of …, 2011 - Elsevier
The lactic acid bacterium Streptococcus thermophilus (S. thermophilus) is widely used in the
dairy industry. As a food bacterium, it has to cope with changing environments such as milk …

CodY-affected transcriptional gene expression of Streptococcus pyogenes during growth in human blood

H Malke, JJ Ferretti - Journal of medical microbiology, 2007 - microbiologyresearch.org
In an attempt to expand the available knowledge of pathogen–host interactions during ex
vivo growth of Streptococcus pyogenes (GAS) in nonimmune whole human blood, the …

Hyperphosphorylation of the group A streptococcal control of virulence regulator increases promoter occupancy specifically at virulence factor-encoding genes

N Horstmann, CN Tran, AR Flores… - Journal of …, 2023 - Am Soc Microbiol
The c ontrol ofv irulence two-component gene regulatory system (CovRS) is critical to the
pathogenesis of many medically important streptococci. In emm1 group A streptococci …