Obesity III: Obesogen assays: Limitations, strengths, and new directions

CD Kassotis, FS Vom Saal, PJ Babin… - Biochemical …, 2022 - Elsevier
There is increasing evidence of a role for environmental contaminants in disrupting
metabolic health in both humans and animals. Despite a growing need for well-understood …

Modulation of peroxisome proliferator-activated receptor gamma (PPAR γ) by conjugated fatty acid in obesity and inflammatory bowel disease

G Yuan, X Chen, D Li - Journal of agricultural and food chemistry, 2015 - ACS Publications
Conjugated fatty acids including conjugated linoleic acid (CLA) and conjugated linolenic
acid (CLNA) have drawn significant attention for their variety of biologically beneficial effects …

A novel antioxidant beverage for body weight control based on coffee silverskin

N Martinez-Saez, M Ullate, MA Martin-Cabrejas… - Food chemistry, 2014 - Elsevier
The present research aimed to add value to coffee silverskin by looking for new innovative
applications. Formulation of novel beverages based on coffee silverskin for body fat …

Phenolic Compounds Reduce the Fat Content in Caenorhabditis elegans by Affecting Lipogenesis, Lipolysis, and Different Stress Responses

P Aranaz, D Navarro-Herrera, M Zabala… - Pharmaceuticals, 2020 - mdpi.com
Supplementation with bioactive compounds capable of regulating energy homeostasis is a
promising strategy to manage obesity. Here, we have screened the ability of different …

Metabolic engineering of β‐carotene in orange fruit increases its in vivo antioxidant properties

E Pons, B Alquézar, A Rodríguez… - Plant Biotechnology …, 2014 - Wiley Online Library
Orange is a major crop and an important source of health‐promoting bioactive compounds.
Increasing the levels of specific antioxidants in orange fruit through metabolic engineering …

Astaxanthin reduces fat storage in a fat-6/fat-7 dependent manner determined using high fat Caenorhabditis elegans

J Xie, X Hou, W He, J Xiao, Y Cao, X Liu - Food & Function, 2023 - pubs.rsc.org
Although astaxanthin has been shown to have high potential for weight loss, the specific
action site and signal pathway generally cannot be confirmed in other animal models. This …

Antidiabetic and anti-obesity properties of a polyphenol-rich flower extract from Tagetes erecta L. and its effects on Caenorhabditis elegans fat storages

S Núñez, C Moliner, MS Valero, AM Mustafa… - Journal of physiology …, 2023 - Springer
Diabetes mellitus (DM) is a metabolic disease characterized by a high blood sugar level that
can cause severe complications to the organism or even death when not treated. However …

Pediococcus acidilactici CECT9879 (pA1c) Counteracts the Effect of a High-Glucose Exposure in C. elegans by Affecting the Insulin Signaling Pathway (IIS)

D Yavorov-Dayliev, FI Milagro, J Ayo, M Oneca… - International Journal of …, 2022 - mdpi.com
The increasing prevalence of metabolic syndrome-related diseases, including type-2
diabetes and obesity, makes it urgent to develop new alternative therapies, such as …

Probiotic strain Bifidobacterium animalis subsp. lactis CECT 8145 reduces fat content and modulates lipid metabolism and antioxidant response in Caenorhabditis …

P Martorell, S Llopis, N González… - Journal of agricultural …, 2016 - ACS Publications
Recently, microbial changes in the human gut have been proposed as a possible cause of
obesity. Therefore, modulation of microbiota through probiotic supplements is of great …

A Cocoa Peptide Protects Caenorhabditis elegans from Oxidative Stress and β-Amyloid Peptide Toxicity

P Martorell, E Bataller, S Llopis, N Gonzalez, B Alvarez… - PloS one, 2013 - journals.plos.org
Background Cocoa and cocoa-based products contain different compounds with beneficial
properties for human health. Polyphenols are the most frequently studied, and display …