From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies
MYB transcription factors are encoded by a large family of highly conserved genes from
plants to vertebrates. There are three members of the MYB gene family in human, namely …
plants to vertebrates. There are three members of the MYB gene family in human, namely …
Analyzing the effects of single nucleotide polymorphisms on hnRNPA2/B1 protein stability and function: insights for anticancer therapeutic design
K Dutta, V Kravtsov, K Oleynikova, A Ruzov… - ACS …, 2024 - ACS Publications
Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is a pivotal player in m6A
recognition, RNA metabolism, and antiviral responses. In the context of cancer …
recognition, RNA metabolism, and antiviral responses. In the context of cancer …
In-Silico Analysis of Deleterious SNPs of FGF4 Gene and Their Impacts on Protein Structure, Function and Bladder Cancer Prognosis
Dysregulation of fibroblast growth factors is linked to the pathogenesis of bladder cancer.
The role of FGF1 and FGF3 is evident in bladder cancer; however, the role of FGF4 is vague …
The role of FGF1 and FGF3 is evident in bladder cancer; however, the role of FGF4 is vague …
An in-silico analysis predicting the impact of coding single nucleotide polymorphisms (SNPs) in the human multidrug pump ABCG2
Abstract ATP-Binding Cassette transporter G2 (ABCG2) is a multidrug resistance pump
involved in pathophysiology and pharmacoresistance in various neurological, and …
involved in pathophysiology and pharmacoresistance in various neurological, and …
Computational screening of pathogenic missense nsSNPs in heme oxygenase 1 (HMOX1) gene and their structural and functional consequences
AK Yadav, TPK Murthy, G Divyashri… - Journal of …, 2024 - Taylor & Francis
Abstract Heme Oxygenase 1 (HMOX1) is a cytoprotective enzyme, exhibiting the highest
activity in the spleen, catalyzing the heme ring breakdown into products of biological …
activity in the spleen, catalyzing the heme ring breakdown into products of biological …
In-silico identification of deleterious non-synonymous SNPs of TBX1 gene: Functional and structural impact towards 22q11.2DS
M Almakhari, Y Chen, ASY Kong, D Moradigaravand… - Plos one, 2024 - journals.plos.org
The TBX1 gene plays a critical role in the development of 22q11. 2 deletion syndrome
(22q11. 2DS), a complex genetic disorder associated with various phenotypic …
(22q11. 2DS), a complex genetic disorder associated with various phenotypic …
[HTML][HTML] Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP) …
Gene mutations are a source of genetic instability which fuels the progression of cancer.
Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of …
Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of …
An integrated computational analysis of high-risk SNPs in angiopoietin-like proteins (ANGPTL3 and ANGPTL8) reveals perturbed protein dynamics associated with …
Angiopoietin-like proteins (ANGPTL) constitute a family of eight proteins (1–8) which play a
pivotal role in the regulation of various pathophysiological processes. The current study …
pivotal role in the regulation of various pathophysiological processes. The current study …
Genome-Wide Identification and Expression Analysis of the MYB Transcription Factor Family in Salvia nemorosa
H Yang, C Chen, L Han, X Zhang, M Yue - Genes, 2024 - mdpi.com
The MYB transcription factor gene family is among the most extensive superfamilies of
transcription factors in plants and is involved in various essential functions, such as plant …
transcription factors in plants and is involved in various essential functions, such as plant …
Expression pattern and clinical value of Key RNA methylation modification regulators in ischemic stroke
X Zhang, Y Wang, B Dong, Y Jiang, D Liu, K Xie… - Frontiers in …, 2022 - frontiersin.org
Ischemic stroke (IS) is one of the major causes of death and disability worldwide, and
effective diagnosis and treatment methods are lacking. RNA methylation, a common …
effective diagnosis and treatment methods are lacking. RNA methylation, a common …