FlyBase (flybase. org) is a knowledge base that supports the community of researchers that
use the fruit fly, Drosophila melanogaster, as a model organism. The FlyBase team curates …

It is easy for today's students and researchers to believe that modern bioinformatics
emerged recently to assist next-generation sequencing data analysis. However, the very …

A critical component in the interpretation of systems-level studies is the inference of enriched
biological pathways and protein complexes contained within OMICs datasets. Successful …

Abstract The Biological General Repository for Interaction Datasets (BioGRID:
https://thebiogrid. org) is an open access database dedicated to the curation and archival …

Constitutive heterochromatin is an important component of eukaryotic genomes that has
essential roles in nuclear architecture, DNA repair and genome stability, and silencing of …

The diversity of cell types and regulatory states in the brain, and how these change during
aging, remains largely unknown. We present a single-cell transcriptome atlas of the entire …

Accurately predicting translation initiation sites (TIS) from genomic sequences is crucial for
understanding gene regulation and function. TIS prediction methods' feature vectors are not …

Abstract NONCODE (http://www. bioinfo. org/noncode/) is a systematic database that is
dedicated to presenting the most complete collection and annotation of non-coding RNAs …

Abstract The HUGO Gene Nomenclature Committee (HGNC) based at EMBL's European
Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes …

By the onset of morphogenesis, Drosophila embryos consist of about 6000 cells that express
distinct gene combinations. Here, we used single-cell sequencing of precisely staged …