Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

Eukaryotic cells have a layer of heterochromatin at the nuclear periphery. To investigate
mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in …

Senescence is a stable proliferation arrest, associated with an altered secretory pathway,
thought to promote tumor suppression and tissue aging. While chromatin regulation and …

Abstract Histone H3 lysine 9 (H3K9) methylation is a conserved modification that generally
represses transcription. In Caenorhabditis elegans it is enriched on silent tissue-specific …

Interphase chromatin is organized in distinct nuclear sub-compartments, reflecting its degree
of compaction and transcriptional status. In Caenorhabditis elegans embryos, H3K9 …

Nuclear lamins are components of the peripheral lamina that define the mechanical
properties of nuclei and tether heterochromatin to the periphery. A-type lamins localize also …

The intermediate filament proteins, A-and B-type lamins, form the nuclear lamina scaffold
adjacent to the inner nuclear membrane. B-type lamins confer elasticity, while A-type lamins …

It is striking that within a eukaryotic nucleus, the genome can assume specific
spatiotemporal distributions that correlate with the cell's functional states. Cell identity itself is …

Chromatin is organized and compacted in the nucleus through the association of histones
and other proteins, which together control genomic activity. Two broad types of chromatin …