Target-based drug design strategies to overcome resistance to antiviral agents: Opportunities and challenges

S Du, X Hu, L Menéndez-Arias, P Zhan, X Liu - Drug Resistance Updates, 2024 - Elsevier
Viral infections have a major impact in human health. Ongoing viral transmission and
escalating selective pressure have the potential to favor the emergence of vaccine-and …

COVID-19 therapeutics

D Focosi, M Franchini, F Maggi… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Since the emergence of COVID-19 in 2020, an unprecedented range of therapeutic options
has been studied and deployed. Healthcare providers have multiple treatment approaches …

SARS-CoV-2 evolution during prolonged infection in immunocompromised patients

AD Marques, J Graham-Wooten, AS Fitzgerald… - Mbio, 2024 - Am Soc Microbiol
Prolonged infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in
immunocompromised patients provides an opportunity for viral evolution, potentially leading …

Deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex

CR Carr, KHD Crawford, M Murphy, JG Galloway… - Immunity, 2024 - cell.com
Lassa virus is estimated to cause thousands of human deaths per year, primarily due to
spillovers from its natural host, Mastomys rodents. Efforts to create vaccines and antibody …

Serum anti‐Spike immunoglobulin G levels in random blood donors in Italy: High‐titre convalescent plasma is easier than ever to procure

D Focosi, S Meschi, S Coen, MC Iorio… - Vox …, 2023 - Wiley Online Library
Background and Objectives COVID‐19 convalescent plasma (CCP) has retained potency
and clinical efficacy against SARS‐CoV‐2 and is currently of utmost value for seronegative …

Sotrovimab: A Review of Its Efficacy against SARS-CoV-2 Variants

D Focosi, A Casadevall, M Franchini, F Maggi - Viruses, 2024 - mdpi.com
Among the anti-Spike monoclonal antibodies (mAbs), the S-309 derivative sotrovimab was
the most successful in having the longest temporal window of clinical use, showing a high …

Clinical and Virological Outcome of Monoclonal Antibody Therapies Across Severe Acute Respiratory Syndrome Coronavirus 2 Variants in 245 Immunocompromised …

S Huygens, C GeurtsvanKessel… - Clinical Infectious …, 2024 - academic.oup.com
Abstract Background Immunocompromised patients (ICPs) have an increased risk for a
severe and prolonged COVID-19. SARS-CoV-2 monoclonal antibodies (mAbs) were …

Analysis of SARS-CoV-2 emergent variants following AZD7442 (tixagevimab/cilgavimab) for early outpatient treatment of COVID-19 (TACKLE Trial)

GH Kijak, B Ahani, D Arbetter, F Chuecos… - Infectious Diseases and …, 2023 - Springer
Abstract Introduction AZD7442 (tixagevimab/cilgavimab) comprises neutralising monoclonal
antibodies (mAbs) that bind to distinct non-overlapping epitopes on the severe acute …

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection

L Yu, Y Wang, Y Liu, X Xing, C Li, X Wang, J Shi, W Ma… - bioRxiv, 2024 - biorxiv.org
Monoclonal antibody (mAb) therapeutics hold promise for both preventing and treating
infectious diseases, especially among vulnerable populations. However, the emergence of …

Clinical and Virological Outcome of Monoclonal Antibody Therapies Across SARS-CoV-2 Variants in 245 Immunocompromised Patients: A Multicenter Prospective …

S Huygens, C GeurtsvanKessel… - Clinical Infectious …, 2024 - academic.oup.com
Abstract Background Immunocompromised patients (ICPs) have an increased risk for a
severe and prolonged COVID-19. SARS-CoV-2 monoclonal antibodies (mAbs) were …