Applied machine learning in Alzheimer's disease research: omics, imaging, and clinical data

Z Li, X Jiang, Y Wang, Y Kim - Emerging topics in life sciences, 2021 - portlandpress.com
Alzheimer's disease (AD) remains a devastating neurodegenerative disease with few
preventive or curative treatments available. Modern technology developments of high …

[HTML][HTML] Scalable causal structure learning: Scoping review of traditional and deep learning algorithms and new opportunities in biomedicine

P Upadhyaya, K Zhang, C Li, X Jiang… - JMIR Medical …, 2023 - medinform.jmir.org
Background: Causal structure learning refers to a process of identifying causal structures
from observational data, and it can have multiple applications in biomedicine and health …

EDVAE: Disentangled latent factors models in counterfactual reasoning for individual treatment effects estimation

Y Liu, J Wang, B Li - Information Sciences, 2024 - Elsevier
Estimating individual treatment effect (ITE) from observational data is a crucial but
challenging task. Disentangled representations have been used to separate proxy variables …

Treatment heterogeneity with survival outcomes

Y Xu, N Ignatiadis, E Sverdrup, S Fleming… - … of Matching and …, 2023 - taylorfrancis.com
This chapter is accompanied by survlearners, a package that provides well-documented
implementations of the conditional average treatment effects (CATE) estimation strategies …

Counterfactual analysis of differential comorbidity risk factors in Alzheimer's disease and related dementias

Y Kim, K Zhang, SI Savitz, L Chen, PE Schulz… - PLOS Digital …, 2022 - journals.plos.org
Alzheimer's disease and related dementias (ADRD) is a multifactorial disease that involves
several different etiologic mechanisms with various comorbidities. There is also significant …

Synthesize heterogeneous biological knowledge via representation learning for Alzheimer's disease drug repurposing

KL Hsieh, G Plascencia-Villa, KH Lin, G Perry, X Jiang… - Iscience, 2023 - cell.com
Developing drugs for treating Alzheimer's disease has been extremely challenging and
costly due to limited knowledge of underlying mechanisms and therapeutic targets. To …

[HTML][HTML] Characterizing Treatment Non-responders vs. Responders in Completed Alzheimer's Disease Clinical Trials

D Wang, Y Ling, K Harris, PE Schulz, X Jiang, Y Kim - medRxiv, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) patients have varying responses to AD drugs and there may be no
single treatment for all AD patients. Trial after trial shows that identifying non-responsive and …

Estimation of subsidiary performance metrics under optimal policies

Z Li, H Nassif, A Luedtke - arXiv preprint arXiv:2401.04265, 2024 - arxiv.org
In policy learning, the goal is typically to optimize a primary performance metric, but other
subsidiary metrics often also warrant attention. This paper presents two strategies for …

Synthesize Heterogeneous Biological Knowledge via Representation Learning for Alzheimer's Disease Drug Repurposing

KL Hsieh, G Plascencia-Villa, KH Lin, G Perry, X Jiang… - medRxiv, 2021 - medrxiv.org
Developing drugs for treating Alzheimer's disease (AD) has been extremely challenging and
costly due to limited knowledge on underlying biological mechanisms and therapeutic …

[PDF][PDF] Estimation and Inference of Optimal Policies

Z Li, A Luedtke, L Jain, K Jamieson - 2024 - digital.lib.washington.edu
We consider the stochastic contextual bandit problem in the PAC setting. Fix a distribution ν
over a potentially countable 1 set of contexts C. The action space is A, and for computational …