RNAi therapeutics have been growing. Patisiran and givosiran, two siRNA-based drugs,
were approved by the Food and Drug Administration in 2018 and 2019, respectively …

Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a
fundamental role in the regulation of bone organogenesis through the activation of receptor …

Gastric cancer is one of the leading causes of cancer mortality in the world. Aberrant
expression of microRNAs (miRNAs) is the hallmark of this disease. MiRNAs are …

Background Metastasis causes the vast majority of colorectal carcinoma (CRC)-related
deaths. However, little is known about the specific traits and underlying mechanisms of …

The transition from ductal carcinoma in situ to invasive ductal carcinoma is a key event in
breast cancer progression that is still not well understood. To discover the microRNAs …

Abstract Background Circular RNAs (circRNAs) have been considered to mediate
occurrence and development of human cancers, generally acting as microRNA (miRNA) …

MicroRNAs (miRNAs) negatively and post-transcriptionally regulate expression of multiple
target genes to support anabolic pathways for bone formation. Here, we show that miR-218 …

Brain metastasis often has a poor prognosis in patients with advanced non-small cell lung
cancer (NSCLC). Therefore, it is urgent to identify factors associated with lung cancer brain …

Background Increasing evidence has revealed that circular RNAs (circRNAs) play crucial
roles in cancer biology. However, the role and underlying regulatory mechanisms of …

Purpose: MicroRNAs (miRNA) have been documented playing a critical role in cancer
development and progression. In this study, we investigate the role of miR-148a in gastric …