A major limitation of organ allotransplantation is the insufficient supply of donor organs.
Consequently, thousands of patients die every year while waiting for a transplant. Progress …

The pig is an omnivorous, monogastric species with many advantages to serve as an animal
model for human diseases. There are very high similarities to humans in anatomy and …

The clinical applicability of porcine xenotransplantation—a long-investigated alternative to
the scarce availability of human organs for patients with organ failure—is limited by …

Transient delivery of CRISPR‐based genome editing effectors is important to reduce off‐
target effects and immune responses. Recently extracellular vesicles (EVs) have been …

Organ allotransplantation has now reached an impassable ceiling inherent to the limited
supply of human donor organs. In the United States, there are currently over 100,000 …

Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart
valves but their susceptibility to structural valve degeneration (SVD) limits their use in young …

Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

Consistent survival of life-supporting pig heart xenograft recipients beyond 90 days was
recently reported using genetically modified pigs and a clinically applicable drug treatment …

The steady progress in genome editing, especially genome editing based on the use of
clustered regularly interspaced short palindromic repeats (CRISPR) and programmable …