[HTML][HTML] Consensus guidelines for the use and interpretation of angiogenesis assays
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …
important roles in growth and development, tissue and organ regeneration, as well as …
[HTML][HTML] CRISPR-based technologies for the manipulation of eukaryotic genomes
The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of
advances in the life sciences that have grown from the ability to edit genomes within living …
advances in the life sciences that have grown from the ability to edit genomes within living …
[HTML][HTML] Enhanced Rice Blast Resistance by CRISPR/Cas9-Targeted Mutagenesis of the ERF Transcription Factor Gene OsERF922
F Wang, C Wang, P Liu, C Lei, W Hao, Y Gao, YG Liu… - PloS one, 2016 - journals.plos.org
Rice blast is one of the most destructive diseases affecting rice worldwide. The adoption of
host resistance has proven to be the most economical and effective approach to control rice …
host resistance has proven to be the most economical and effective approach to control rice …
CRISPR/Cas systems in genome editing: methodologies and tools for sgRNA design, off‐target evaluation, and strategies to mitigate off‐target effects
H Manghwar, B Li, X Ding, A Hussain… - Advanced …, 2020 - Wiley Online Library
Life sciences have been revolutionized by genome editing (GE) tools, including zinc finger
nucleases, transcription activator‐Like effector nucleases, and CRISPR (clustered regulatory …
nucleases, transcription activator‐Like effector nucleases, and CRISPR (clustered regulatory …
[HTML][HTML] Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs
The CRISPR/Cas9 system has been implemented in a variety of model organisms to
mediate site-directed mutagenesis. A wide range of mutation rates has been reported, but at …
mediate site-directed mutagenesis. A wide range of mutation rates has been reported, but at …
Zebrafish as an emerging model for studying complex brain disorders
AV Kalueff, AM Stewart, R Gerlai - Trends in pharmacological sciences, 2014 - cell.com
The zebrafish (Danio rerio) is rapidly becoming a popular model organism in
pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently …
pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently …
CRISPR/Cas9 for genome editing: progress, implications and challenges
F Zhang, Y Wen, X Guo - Human molecular genetics, 2014 - academic.oup.com
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
(Cas) protein 9 system provides a robust and multiplexable genome editing tool, enabling …
(Cas) protein 9 system provides a robust and multiplexable genome editing tool, enabling …
[HTML][HTML] Detection of on-target and off-target mutations generated by CRISPR/Cas9 and other sequence-specific nucleases
The development of customizable sequence-specific nucleases such as TALENs, ZFNs and
the powerful CRISPR/Cas9 system has revolutionized the field of genome editing. The …
the powerful CRISPR/Cas9 system has revolutionized the field of genome editing. The …
Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in Arabidopsis
Z Feng, Y Mao, N Xu, B Zhang, P Wei… - Proceedings of the …, 2014 - National Acad Sciences
The CRISPR (clustered regularly interspaced short palindromic repeat)/Cas (CRISPR-
associated) system has emerged as a powerful tool for targeted gene editing in many …
associated) system has emerged as a powerful tool for targeted gene editing in many …
[HTML][HTML] Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9
Genome editing via CRISPR/Cas9 has rapidly become the tool of choice by virtue of its
efficacy and ease of use. However, CRISPR/Cas9-mediated genome editing in clinically …
efficacy and ease of use. However, CRISPR/Cas9-mediated genome editing in clinically …