The electronic properties and relatively small size of fluorine endow it with considerable
versatility as a bioisostere and it has found application as a substitute for lone pairs of …

Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

Structural analysis of modern pharmaceutical practices allows for the identification of two
rapidly growing trends: the introduction of tailor‐made amino acids and the exploitation of …

In modern organic synthesis chromatographic separation of crude reaction products has
largely supplanted the more time-consuming development of an efficient crystallization. 1 As …

Alkylations of chiral or achiral Ni (II) complexes of glycine Schiff bases constitute a landmark
in the development of practical methodology for asymmetric synthesis of α-amino acids …

Side chain-fluorinated amino acids are useful tools in medicinal chemistry and protein
science. In this review, we outline some general strategies for incorporating fluorine atom (s) …

Owing to a faster rate of sublimation of the racemic form as compared to the optically pure
form, optical purification occurred without any external action or special environmental …

This review article provides a critical overview of several different synthetic approaches
developed for asymmetric preparation of fluorine-containing amines, amino alcohols, α-and …

Abstract Development of synthetic methodology for preparation of enantiomerically pure
fluorine containing amino acids (FAAs) is one of the most actively pursued areas of …

1 Introduction 2 α-Amino acids with hydrocarbon side-chains (alanine, glycine, leucine,
phenylalanine and valine) 3 α-Amino acids with aliphatic hydroxylated or thiolated side …