Adipocyte determination and differentiation-dependent factor 1 (ADD1) is a member of the
basic helix-loop-helix leucine zipper (bHLH-LZ) family of transcription factors that binds to …

We have defined two principles of corepressor function that account for differences in
transcriptional repression by nuclear hormone receptors (NHRs). First, we have determined …

LXR is an orphan nuclear receptor that confers retinoid responsiveness to the retinoid X
receptor (RXR) by its interaction on a specific response element called an LXRE. To …

Regulation of gene expression via allosteric control of transcription is one of the
fundamental concepts of molecular biology. Studies in prokaryotes have illustrated that …

Estrogen has diverse effects on inflammation and immune responses. That pregnancy is
associated with remission of some autoimmune diseases and exacerbation of others …

Transcriptional activation of the prolactin and growth hormone genes, occurring in a cell-
specific fashion, requires short-range synergistic interactions between the pituitary-specific …

While estrogen receptor (ER) profile plays an important role in response to estrogens,
receptor coregulators act as critical determinants of signaling. Although the clinical effects of …

Many carcinogens have been shown to cause tissue specific tumors in animal models. The
mechanism for this specificity has not been fully elucidated and is usually attributed to …