Early life exposure to per-and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of …

BE Blake, SE Fenton - Toxicology, 2020 - Elsevier
Per-and polyfluoroalkyl substances (PFAS) are ubiquitous drinking water contaminants of
concern due to mounting evidence implicating adverse health outcomes associated with …

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary

N Ding, SD Harlow, JF Randolph Jr… - Human …, 2020 - academic.oup.com
BACKGROUND Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are found widespread
in drinking water, foods, food packaging materials and other consumer products. Several …

Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2018 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific evaluation on the risks to
human health related to the presence of perfluorooctane sulfonic acid (PFOS) and …

[HTML][HTML] Exposure to perfluorinated alkyl substances and health outcomes in children: a systematic review of the epidemiologic literature

KM Rappazzo, E Coffman, EP Hines - International journal of …, 2017 - mdpi.com
Perfluoroalkyl substances (PFAS), chemicals used to make products stain and stick
resistant, have been linked to health effects in adults and adverse birth outcomes. A growing …

Assessing the human health risks of per-and polyfluoroalkyl substances: a need for greater focus on their interactions as mixtures

AF Ojo, C Peng, JC Ng - Journal of Hazardous Materials, 2021 - Elsevier
Humans are exposed to complex mixtures of per-and polyfluoroalkyl substances (PFAS).
However, human health risk assessment of PFAS currently relies on animal toxicity data …

[HTML][HTML] Effects of endocrine disrupting chemicals on gonad development: Mechanistic insights from fish and mammals

G Delbes, M Blázquez, JI Fernandino, P Grigorova… - Environmental …, 2022 - Elsevier
Over the past century, evidence has emerged that endocrine disrupting chemicals (EDCs)
have an impact on reproductive health. An increased frequency of reproductive disorders …

Bioactivity profiling of per-and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure

KA Houck, G Patlewicz, AM Richard, AJ Williams… - Toxicology, 2021 - Elsevier
Per-and polyfluoroalkyl substances (PFAS) are a broad class of hundreds of fluorinated
chemicals with environmental health concerns due to their widespread presence and …

Comparative toxicometabolomics of perfluorooctanoic acid (PFOA) and next-generation perfluoroalkyl substances

KY Gebreab, MNH Eeza, T Bai, Z Zuberi, J Matysik… - Environmental …, 2020 - Elsevier
Owing to environmental health concerns, a number of per-and polyfluoroalkyl substances
(PFAS) have been phased-out, and increasingly replaced by various chemical analogs …

[HTML][HTML] Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) acutely affect human α1β2γ2L GABAA receptor and spontaneous neuronal network …

AM Tukker, LMS Bouwman, RGDM van Kleef… - Scientific reports, 2020 - nature.com
Concerns about the neurotoxic potential of polyfluoroalkyl substances (PFAS) such as
perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) increase, although …

Perfluorooctanoic acid disrupts gap junction intercellular communication and induces reactive oxygen species formation and apoptosis in mouse ovaries

P López‐Arellano, K López‐Arellano… - Environmental …, 2019 - Wiley Online Library
Perfluorooctanoic acid (PFOA) is a member of the perfluoroalkyl acid family of compounds.
Due to the presence of strong carbon–fluorine bonds, it is practically nonbiodegradable and …