Disentangling heterogeneity in Alzheimer's disease and related dementias using data-driven methods

M Habes, MJ Grothe, B Tunc, C McMillan, DA Wolk… - Biological …, 2020 - Elsevier
Brain aging is a complex process that includes atrophy, vascular injury, and a variety of age-
associated neurodegenerative pathologies, together determining an individual's course of …

Pathological influences on clinical heterogeneity in Lewy body diseases

DG Coughlin, HI Hurtig, DJ Irwin - Movement Disorders, 2020 - Wiley Online Library
ABSTRACT PD, PD with dementia, and dementia with Lewy bodies are clinical syndromes
characterized by the neuropathological accumulation of alpha‐synuclein in the CNS that …

Sex differences in dementia with Lewy bodies: focused review of available evidence and future directions

SY Chiu, KA Wyman-Chick, TJ Ferman… - Parkinsonism & related …, 2023 - Elsevier
In this review, we summarize the current knowledge on sex differences in dementia with
Lewy bodies (DLB) relating to epidemiology, clinical features, neuropathology, biomarkers …

Neuropsychological and electrophysiological measurements for diagnosis and prediction of dementia: a review on Machine Learning approach

C Carrarini, C Nardulli, L Titti, F Iodice, F Miraglia… - Ageing Research …, 2024 - Elsevier
Introduction Emerging and advanced technologies in the field of Artificial Intelligence (AI)
represent promising methods to predict and diagnose neurodegenerative diseases, such as …

The temporal onset of the core features in dementia with Lewy bodies

P Choudhury, J Graff‐Radford, JA Aakre… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction We examined the temporal sequence of the core features in probable dementia
with Lewy bodies (DLB). Methods In 488 patients with probable DLB, the onset of each core …

Parsing heterogeneity within dementia with Lewy bodies using clustering of biological, clinical, and demographic data

C Abdelnour, D Ferreira, M van de Beek… - Alzheimer's research & …, 2022 - Springer
Abstract Background Dementia with Lewy bodies (DLB) includes various core clinical
features that result in different phenotypes. In addition, Alzheimer's disease (AD) and …

Clinical and video-polysomnographic analysis of rapid eye movement sleep behavior disorder and other sleep disturbances in dementia with Lewy bodies

A Fernández-Arcos, E Morenas-Rodríguez… - Sleep, 2019 - academic.oup.com
Objective The main objective of this study was to study rapid eye movement (REM) sleep
behavior disorder (RBD) and other sleep disorders in dementia with Lewy bodies (DLB) …

Clinical features of Lewy body dementia: insights into diagnosis and pathophysiology

E Matar, KA Ehgoetz Martens, GM Halliday… - Journal of …, 2020 - Springer
Introduction The recent revision of the consensus diagnostic criteria for dementia with Lewy
bodies (DLB) incorporates an expansive set of core and supportive clinical features …

Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer's disease

E Morenas-Rodríguez, D Alcolea, M Suárez-Calvet… - Scientific reports, 2019 - nature.com
The role of innate immunity in dementia with Lewy bodies (DLB) has been little studied. We
investigated the levels in cerebrospinal fluid (CSF) of glial proteins YKL-40, soluble TREM2 …

Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology

SE Mastenbroek, JW Vogel, LE Collij… - Nature …, 2024 - nature.com
Lewy body (LB) diseases, characterized by the aggregation of misfolded α-synuclein
proteins, exhibit notable clinical heterogeneity. This may be due to variations in …