With a growing aged population, there is an imminent need to develop new therapeutic
strategies to ameliorate disorders of hematopoietic aging, including clonal hematopoiesis …

Classically, platelets have been described as the cellular blood component that mediates
hemostasis and thrombosis. This important platelet function has received significant …

In cancer biology, tumor-promoting inflammation and an inflammatory microenvironment
play a vital role in disease pathogenesis. In the past decade, aberrant innate immune …

Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of
cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDSs is …

Chronic innate immune signaling in hematopoietic cells is widely described in
myelodysplastic syndromes (MDS), and innate immune pathway activation, predominantly …

Megakaryocytes (MKs), the platelet progenitor cells, play important roles in hematopoietic
stem cell (HSC) maintenance and immunity. However, it is not known whether these diverse …

Mesenchymal niche cells may drive tissue failure and malignant transformation in the
hematopoietic system, but the underlying molecular mechanisms and relevance to human …

Abstract 5q–syndrome is a subtype of myelodysplastic syndrome characterized by severe
anemia and variable neutropenia but normal or high platelet counts with dysplastic …

During systemic infection and inflammation, immune effector cells are in high demand and
are rapidly consumed at sites of need. Although adaptive immune cells have high …

Myelodysplastic syndromes (MDS) are age-dependent stem cell malignancies that share
biological features of activated adaptive immune response and ineffective hematopoiesis …