Gut barrier disruption and chronic disease

J Martel, SH Chang, YF Ko, TL Hwang… - Trends in Endocrinology …, 2022 - cell.com
The intestinal barrier protects the host against gut microbes, food antigens, and toxins
present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …

The intestinal barrier and current techniques for the assessment of gut permeability

I Schoultz, ÅV Keita - Cells, 2020 - mdpi.com
The intestinal barrier is essential in human health and constitutes the interface between the
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …

Suicide and suicide risk

G Turecki, DA Brent, D Gunnell, RC O'Connor… - Nature reviews Disease …, 2019 - nature.com
Although recent years have seen large decreases in the overall global rate of suicide
fatalities, this trend is not reflected everywhere. Suicide and suicidal behaviour continue to …

Altered composition of gut microbiota in depression: a systematic review

ZA Barandouzi, AR Starkweather… - Frontiers in …, 2020 - frontiersin.org
Cumulative evidence shows a linkage between gut microbiota pattern and depression
through the brain-gut microbiome axis. The aim of this systematic review was to identify the …

Role of the gut microbiome in three major psychiatric disorders

J Borkent, M Ioannou, JD Laman… - Psychological …, 2022 - cambridge.org
Major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia-spectrum
disorders (SSD) are heterogeneous psychiatric disorders, which place significant burden on …

Antidepressive mechanisms of probiotics and their therapeutic potential

SJ Yong, T Tong, J Chew, WL Lim - Frontiers in neuroscience, 2020 - frontiersin.org
The accumulating knowledge of the host-microbiota interplay gives rise to the microbiota-gut-
brain (MGB) axis. The MGB axis depicts the interkingdom communication between the gut …

Stress triggers flare of inflammatory bowel disease in children and adults

Y Sun, L Li, R Xie, B Wang, K Jiang, H Cao - Frontiers in pediatrics, 2019 - frontiersin.org
Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease characterized by
chronic and relapsing manifestations. It is noteworthy that the prevalence of IBD is gradually …

PROVIT: Supplementary probiotic treatment and vitamin B7 in depression—A randomized controlled trial

EZ Reininghaus, M Platzer, A Kohlhammer-Dohr… - Nutrients, 2020 - mdpi.com
Gut microbiota are suspected to affect brain functions and behavior as well as lowering
inflammation status. Therefore, an effect on depression has already been suggested by …

Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis

JM Safadi, AMG Quinton, BR Lennox, PWJ Burnet… - Molecular …, 2022 - nature.com
Reduced gut-microbial diversity (“gut dysbiosis”) has been associated with an anhedonic/
amotivational syndrome (“sickness behavior”) that manifests across severe mental disorders …

Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour

JK Knudsen, TY Michaelsen, C Bundgaard-Nielsen… - Scientific reports, 2021 - nature.com
Differences in gut microbiota composition have been observed in patients with major
depressive disorder (MDD) compared to healthy individuals. Here, we investigated if faecal …