The mechanism of initiation of translation differs between prokaryotes and eukaryotes, and
the strategies used for regulation differ accordingly. Translation in prokaryotes is usually …

Recent studies are reviewed indicating that the transcription factor early growth response-1
(Egr1) is a direct regulator of multiple tumor suppressors including TGFβ1, PTEN, p53, and …

The PI3K pathway regulates cell metabolism, proliferation, and migration, and its
dysregulation is common in cancer. We now show that both physiologic and oncogenic …

The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …

Recent studies conducted over the past 10 years evidence the intriguing role of the tumor
suppressor gene Phosphatase and Tensin Homolog deleted on Chromosome 10 PTEN in …

The tumor suppressor PTEN encodes a lipid phosphatase that negatively regulates the
phosphatidylinositol 3-kinase/AKT cell survival pathway. Mutations of this gene are common …

Abstract About 25–50% of women with Cowden disease, a syndrome associated with germ‐
line mutations of the PTEN gene (at 10q23), develop breast cancer (BC), but PTEN …

Rationale: Myofibroblasts are primary effector cells in idiopathic pulmonary fibrosis (IPF).
Defining mechanisms of myofibroblast differentiation may be critical to the development of …

Phosphatase and tensin homolog (PTEN) is a regulator of phosphoinositide 3‐kinase
signaling and an important tumor suppressor mutated/deleted in human cancers. PTEN …

Activation of c-Jun, a component of the AP-1 family of transcription factors, leads to either
promotion or prevention of apoptosis. However, the molecular determinants of c-Jun …