Modern neuropsychopharmacology commenced in the 1950s with the serendipitous
discovery of first-generation antipsychotics and antidepressants which were therapeutically …

Highlights•Functional MRI continues to have the potential to play a useful role in developing
novel compounds.•But the lack of consensus on optimal techniques for acquisition and …

Major depressive disorder is a disabling psychiatric condition that causes a significant
burden on individuals and society. There is still a lack of a clear understanding of the …

Aims An abnormal activity in the electroencephalography (EEG) gamma band (> 30 Hz) has
been demonstrated in schizophrenia and this has been suggested to be reflecting a deficit in …

Selective negative allosteric modulators (NAMs) targeting the metabotropic glutamate
receptor subtype 5 (mGlu5) demonstrate anxiolytic-like and antidepressant-like effects yet …

Sex-and age-related differences in symptom prevalence and severity have been widely
reported in patients with schizophrenia, yet the underlying mechanisms contributing to these …

(DSM), which is commonly referred to as the bible of psychiatry [1]. Now in its fifth edition,
DSM enables clinicians to diagnose psychiatric problems based on a list of symptoms that …

Advances in biotechnology have enabled us to assay human tissue and cells to a depth and
resolution that was never possible before, redefining what we know as the “biomarker”, and …

Mirror neuron system (MNS) has been demonstrated to be defective in patients with
schizophrenia. This paper report findings from a high resolution (192-channel) EEG study …

Functional magnetic resonance imaging (fMRI) of the brain is a technology that holds great
potential for increasing the efficiency of drug development for the central nervous system …