In this article strategies for the design and synthesis of natural product analogues are
summarized and illustrated with some selected examples. Proven strategies include …

Covalent inhibitors are re-emerging as pharmacologically interesting entities with several
candidates having received recent approval for therapeutic intervention. Nature has …

Receptor tyrosine kinases represent one of the prime targets in cancer therapy, as the
dysregulation of these elementary transducers of extracellular signals, like the epidermal …

The Janus kinases (JAKs) and their downstream effectors, signal transducer and activator of
transcription proteins (STATs), form a critical immune cell signaling circuit, which is of …

DNA-encoded chemical libraries are increasingly used to identify leads for drug discovery or
chemical biology. Despite the resurging interest in covalent inhibitors, libraries are typically …

We developed a near-infrared fluorescence probe for the highly selective and sensitive
detection of NAT2 activity. An arylamine was designed as the substrate part for NATs, as …

Dimeric proteins are prominent in biology, and receptor dimerization (homo-or
heterodimerization) is central to signal transduction. Herein, we report a network that …

Efficient access to proteins modified site-specifically with glycans is important in
glycobiology and for therapeutic applications. Herein, we report a biocompatible protein …

Bioluminescence resonance energy transfer (BRET) has been widely used for studying
dynamic processes in biological systems such as protein–protein interactions and other …

Janus kinases (JAKs) are a family of four cytosolic protein kinases with a high degree of
structural similarity. Due to its very restricted role in immune regulation, JAK3 was promoted …