Maternal obesity and diabetes mellitus as risk factors for congenital heart disease in the offspring

E Helle, JR Priest - Journal of the American Heart Association, 2020 - Am Heart Assoc
Congenital heart disease (CHD) is the most common anatomical malformation occurring live‐
born infants and an increasing cause of morbidity and mortality across the lifespan and …

Maternal hyperglycemia and fetal cardiac development: Clinical impact and underlying mechanisms

M Basu, V Garg - Birth defects research, 2018 - Wiley Online Library
Congenital heart disease (CHD) is the most common type of birth defect and is both a
significant pediatric and adult health problem, in light of a growing population of survivors …

Effect of maternal diabetes on fetal heart function on echocardiography: systematic review and meta‐analysis

AL Depla, L De Wit, TJ Steenhuis… - … in obstetrics & …, 2021 - Wiley Online Library
Objective Maternal diabetes in pregnancy is associated with structural anomalies of the fetal
heart, as well as hypertrophy and functional impairment. This systematic review and meta …

Role of epigenetics in cardiac development and congenital diseases

T Moore-Morris, PP van Vliet… - Physiological …, 2018 - journals.physiology.org
The heart is the first organ to be functional in the fetus. Heart formation is a complex
morphogenetic process regulated by both genetic and epigenetic mechanisms. Congenital …

[HTML][HTML] Genetics of congenital heart disease: a narrative review of recent advances and clinical implications

J Yasuhara, V Garg - Translational Pediatrics, 2021 - ncbi.nlm.nih.gov
Congenital heart disease (CHD) is the most common human birth defect and remains a
leading cause of mortality in childhood. Although advances in clinical management have …

Molecular genetic mechanisms of congenital heart disease

TZ Choudhury, V Garg - Current opinion in genetics & development, 2022 - Elsevier
Congenital heart disease (CHD) affects~ 1% of all live births, but a definitive etiology is
identified in only~ 50%. The causes include chromosomal aneuploidies and copy-number …

Risk of congenital heart defects in offspring exposed to maternal diabetes mellitus: an updated systematic review and meta-analysis

L Chen, T Yang, L Chen, L Wang, T Wang… - Archives of gynecology …, 2019 - Springer
Purpose A systematic review and meta-analysis was performed to assess the risk of
congenital heart defects (CHDs) and its specific phenotypes associated with maternal …

Periconception glycaemic control in women with type 1 diabetes and risk of major birth defects: population based cohort study in Sweden

JF Ludvigsson, M Neovius, J Söderling… - bmj, 2018 - bmj.com
Objective To examine the association between maternal type 1 diabetes and the risk of
major birth defects according to levels of glycated haemoglobin (HbA1C) within three …

[HTML][HTML] Epigenetics and mechanobiology in heart development and congenital heart disease

DK Jarrell, ML Lennon, JG Jacot - Diseases, 2019 - mdpi.com
Congenital heart disease (CHD) is the most common birth defect worldwide and the number
one killer of live-born infants in the United States. Heart development occurs early in …

[HTML][HTML] Say NO to ROS: Their roles in embryonic heart development and pathogenesis of congenital heart defects in maternal diabetes

A Engineer, T Saiyin, ER Greco, Q Feng - Antioxidants, 2019 - mdpi.com
Congenital heart defects (CHDs) are the most prevalent and serious birth defect, occurring
in 1% of all live births. Pregestational maternal diabetes is a known risk factor for the …