Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic and an important
risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic …

Pancreatic islet β cells secrete insulin in response to nutrient secretagogues, like glucose,
dependent on calcium influx and nutrient metabolism. One of the most intriguing qualities of …

Although induction of ferroptosis, an iron-dependent form of non-apoptotic cell death, has
emerged as an anticancer strategy, the metabolic basis of ferroptotic death remains poorly …

Highly conserved signalling pathways controlled by mammalian target of rapamycin (mTOR)
and AMP-activated protein kinase (AMPK) are central to cellular metabolism and cell …

The AMP-activated protein kinase (AMPK) acts as a cellular energy sensor. Once switched
on by increases in cellular AMP: ATP ratios, it acts to restore energy homeostasis by …

Abstract The SnRK1 (SNF1-related kinase 1) kinases are the plant cellular fuel gauges,
activated in response to energy-depleting stress conditions to maintain energy homeostasis …

Inhibition of the metabolic regulator AMP-activated protein kinase (AMPK) is increasingly
being investigated for its therapeutic potential in diseases where AMPK hyperactivity results …

The AMP-activated protein kinase (AMPK) is a heterotrimeric complex with central roles in
cellular energy sensing and the regulation of metabolism and exercise adaptations. AMPK …

Mitochondria play vital roles in various cellular processes, ranging from cellular metabolism
to signal transduction and cell death regulation. As these properties are critical for cancer …

Despite significant advances in our understanding of the biology determining systemic
energy homeostasis, the treatment of obesity remains a medical challenge. Activation of …