The default mode network in autism
Autism spectrum disorder (ASD) is characterized by deficits in social communication and
interaction. Since its discovery as a major functional brain system, the default mode network …
interaction. Since its discovery as a major functional brain system, the default mode network …
Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling
Rett syndrome (RTT) is an X-linked, neurodevelopmental disorder caused primarily by
mutations in the methyl-CpG-binding protein 2 (MECP2) gene, which encodes a …
mutations in the methyl-CpG-binding protein 2 (MECP2) gene, which encodes a …
Neural variability: friend or foe?
Although we may not realize it, our brain function varies markedly from moment to moment
such that our brain responses exhibit substantial variability across trials even in response to …
such that our brain responses exhibit substantial variability across trials even in response to …
Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder
MV Lombardo, HM Moon, J Su, TD Palmer… - Molecular …, 2018 - nature.com
Maternal immune activation (MIA) via infection during pregnancy is known to increase risk
for autism spectrum disorder (ASD). However, it is unclear how MIA disrupts fetal brain gene …
for autism spectrum disorder (ASD). However, it is unclear how MIA disrupts fetal brain gene …
Cerebral organoid and mouse models reveal a RAB39b–PI3K–mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism …
Dysregulation of early neurodevelopment is implicated in macrocephaly/autism disorders.
However, the mechanism underlying this dysregulation, particularly in human cells, remains …
However, the mechanism underlying this dysregulation, particularly in human cells, remains …
Gastrointestinal symptoms and autism spectrum disorder: links and risks–a possible new overlap syndrome
J Wasilewska, M Klukowski - Pediatric health, medicine and …, 2015 - Taylor & Francis
Autism spectrum disorder (ASD) is a genetically determined neurodevelopmental brain
disorder presenting with restricted, repetitive patterns of behaviors, interests, and activities …
disorder presenting with restricted, repetitive patterns of behaviors, interests, and activities …
Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept
F Pistollato, EM de Gyves, D Carpi, SK Bopp… - Environmental …, 2020 - Springer
Background In light of the vulnerability of the developing brain, mixture risk assessment
(MRA) for the evaluation of developmental neurotoxicity (DNT) should be implemented …
(MRA) for the evaluation of developmental neurotoxicity (DNT) should be implemented …
The over‐pruning hypothesis of autism
MSC Thomas, R Davis, A Karmiloff‐Smith… - Developmental …, 2016 - Wiley Online Library
This article outlines the over‐pruning hypothesis of autism. The hypothesis originates in a
neurocomputational model of the regressive sub‐type (Thomas, Knowland & Karmiloff …
neurocomputational model of the regressive sub‐type (Thomas, Knowland & Karmiloff …
Neocortical neurogenesis and the etiology of autism spectrum disorder
A Packer - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
Researchers have now identified many highly penetrant genetic risk factors for autism
spectrum disorder (ASD). Some of these genes encode synaptic proteins, lending support to …
spectrum disorder (ASD). Some of these genes encode synaptic proteins, lending support to …