Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

Amyotrophic lateral sclerosis (ALS) encompasses a heterogeneous group of phenotypes
with different progression rates, varying degree of extra-motor involvement and divergent …

Summary Background CNM-Au8® is a catalytically-active gold nanocrystal neuroprotective
agent that enhances intracellular energy metabolism and reduces oxidative stress. The …

Background Motor Unit Number Index (MUNIX) is a novel neurophysiological measure that
provides an index of the number of functional lower motor neurons in a given muscle. So far …

Objective To examine inter-and intra-rater reproducibility and sensitivity to motor unit loss of
a novel motor unit number estimation (MUNE) method, MScanFit MUNE (MScan), compared …

Introduction Amyotrophic lateral sclerosis (ALS) is an adult-onset, progressive and
universally fatal neurodegenerative disorder. In Europe, Australia and Canada, riluzole is …

Thoughtful clinical trial design is critical for efficient therapeutic development, particularly in
the field of amyotrophic lateral sclerosis (ALS), where trials often aim to detect modest …

Abstract Objective Motor Unit Number Index (MUNIX) is a quantitative neurophysiological
measure that provides an index of the number of lower motor neurons supplying a muscle. It …

The interrelationship between muscle strength, motor unit (MU) number, and age is poorly
understood, and in this study we sought to determine whether age-related differences in …

Objective Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease
that leads to inexorable motor decline and a median survival of three years from symptom …