A computational approach to understanding the cardiac electromechanical activation sequence in the normal and failing heart, with translation to the clinical practice …
J Constantino, Y Hu, NA Trayanova - Progress in biophysics and molecular …, 2012 - Elsevier
Cardiac resynchronization therapy (CRT) is an established clinical treatment modality that
aims to recoordinate contraction of the heart in dyssynchrous heart failure (DHF) patients …
aims to recoordinate contraction of the heart in dyssynchrous heart failure (DHF) patients …
Applications of computational modeling in cardiac surgery
Although computational modeling is common in many areas of science and engineering,
only recently have advances in experimental techniques and medical imaging allowed this …
only recently have advances in experimental techniques and medical imaging allowed this …
Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments
Ventricular wall stress is believed to be responsible for many physical mechanisms taking
place in the human heart, including ventricular remodeling, which is frequently associated …
place in the human heart, including ventricular remodeling, which is frequently associated …
Algisyl-LVR™ with coronary artery bypass grafting reduces left ventricular wall stress and improves function in the failing human heart
Background Left ventricular (LV) wall stress reduction is a cornerstone in treating heart
failure. Large animal models and computer simulations indicate that adding non-contractile …
failure. Large animal models and computer simulations indicate that adding non-contractile …
Growth and remodeling of the left ventricle: a case study of myocardial infarction and surgical ventricular restoration
Cardiac growth and remodeling in the form of chamber dilation and wall thinning are typical
hallmarks of infarct-induced heart failure. Over time, the infarct region stiffens, the remaining …
hallmarks of infarct-induced heart failure. Over time, the infarct region stiffens, the remaining …
Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling
Z Zhang, A Tendulkar, K Sun, DA Saloner… - The Annals of thoracic …, 2011 - Elsevier
BACKGROUND: Both the Young-Laplace law and finite element (FE) based methods have
been used to calculate left ventricular wall stress. We tested the hypothesis that the Young …
been used to calculate left ventricular wall stress. We tested the hypothesis that the Young …
A novel method for quantifying smooth regional variations in myocardial contractility within an infarcted human left ventricle based on delay-enhanced magnetic …
M Genet, L Chuan Lee, L Ge… - Journal of …, 2015 - asmedigitalcollection.asme.org
Heart failure is increasing at an alarming rate, making it a worldwide epidemic. As the
population ages and life expectancy increases, this trend is not likely to change. Myocardial …
population ages and life expectancy increases, this trend is not likely to change. Myocardial …
Impact of surgical ventricular restoration on ventricular shape, wall stress, and function in heart failure patients
Surgical ventricular restoration (SVR) was designed to treat patients with aneurysms or large
akinetic walls and dilated ventricles. Yet, crucial aspects essential to the efficacy of this …
akinetic walls and dilated ventricles. Yet, crucial aspects essential to the efficacy of this …
Infarct Size Determines Myocardial Uptake of CD34+ Cells in the Peri-Infarct Zone: Results From a Study of 99mTc-extametazime–Labeled Cell Visualization …
P Musialek, L Tekieli, M Kostkiewicz… - Circulation …, 2013 - Am Heart Assoc
Background—Effective progenitor cell recruitment to the ischemic injury zone is a
prerequisite for any potential therapeutic effect. Cell uptake determinants in humans with …
prerequisite for any potential therapeutic effect. Cell uptake determinants in humans with …
Optimizing epicardial restraint and reinforcement following myocardial infarction: moving towards localized, biomimetic, and multitherapeutic options
The mechanical reinforcement of the ventricular wall after a myocardial infarction has been
shown to modulate and attenuate negative remodeling that can lead to heart failure …
shown to modulate and attenuate negative remodeling that can lead to heart failure …