Adipokines, adiposity, and atherosclerosis

L Liu, Z Shi, X Ji, W Zhang, J Luan, T Zahr… - Cellular and Molecular …, 2022 - Springer
Characterized by a surplus of whole-body adiposity, obesity is strongly associated with the
prognosis of atherosclerosis, a hallmark of coronary artery disease (CAD) and the major …

Targeted intervention of natural medicinal active ingredients and traditional Chinese medicine on epigenetic modification: possible strategies for prevention and …

W Wang, H Li, Y Shi, J Zhou, GJ Khan, J Zhu, F Liu… - Phytomedicine, 2024 - Elsevier
Background Atherosclerosis is a deadly consequence of cardiovascular disease and has
very high mortality rate worldwide. The epigenetic modifications can regulate the …

Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway

H Lu, C Jia, D Wu, H Jin, Z Lin, J Pan, X Li… - Cell Death & …, 2021 - nature.com
Osteoarthritis (OA) is a complex condition that involves both apoptosis and senescence and
currently cannot be cured. Fibroblast growth factor 21 (FGF21), known for its role as a potent …

[HTML][HTML] Targeting FGF21 in cardiovascular and metabolic diseases: from mechanism to medicine

H Tan, T Yue, Z Chen, W Wu, S Xu… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Cardiovascular and metabolic disease (CVMD) is becoming increasingly prevalent in
developed and developing countries with high morbidity and mortality. In recent years …

FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis

Z Zeng, Q Zheng, J Chen, X Tan, Q Li, L Ding… - Experimental cell …, 2020 - Elsevier
Abstract Fibroblast growth factor 21 (FGF21) is an endocrine cytokine that targets
inflammation and atherosclerosis (AS). However, the underlying molecular mechanisms of …

The role of FGF21 and its analogs on liver associated diseases

K Falamarzi, M Malekpour, MF Tafti, N Azarpira… - Frontiers in …, 2022 - frontiersin.org
Fibroblast growth factor 21 (FGF21), a member of fibroblast growth factor family, is a
hormone-like growth factor that is synthesized mainly in the liver and adipose tissue. FGF21 …

Aerobic exercise regulates FGF21 and NLRP3 inflammasome-mediated pyroptosis and inhibits atherosclerosis in mice

XH Li, LZ Liu, L Chen, QN Pan, ZY Ouyang, DJ Fan… - PloS one, 2022 - journals.plos.org
Fibroblast growth factor 21 (FGF21), a known risk factor for atherosclerosis, is readily
regulated by exercise, and it can inhibit NOD-like receptor protein 3 (NLRP3)-mediated …

FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival

K Zhou, H Chen, J Lin, H Xu, H Wu, G Bao, J Li… - Cell death & …, 2019 - nature.com
Random-pattern skin flap is commonly used for surgical tissue reconstruction due to its ease
and lack of axial vascular limitation. However, ischemic necrosis is a common complication …

FGF21 induces autophagy‐mediated cholesterol efflux to inhibit atherogenesis via RACK1 up‐regulation

L Xiaolong, G Dongmin, M Liu, W Zuo… - Journal of cellular …, 2020 - Wiley Online Library
Abstract Fibroblast growth factor 21 (FGF21) acts as an anti‐atherosclerotic agent. However,
the specific mechanisms governing this regulatory activity are unclear. Autophagy is a highly …

Mitochondrial lipid homeostasis at the crossroads of liver and heart diseases

SA Dabravolski, EE Bezsonov, MS Baig… - International Journal of …, 2021 - mdpi.com
The prevalence of NAFLD (non-alcoholic fatty liver disease) is a rapidly increasing problem,
affecting a huge population around the globe. However, CVDs (cardiovascular diseases) …