Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology
MI Ivanova, Y Lin, YH Lee, J Zheng… - Biophysical chemistry, 2021 - Elsevier
Abnormal aggregation of proteins into filamentous aggregates commonly associates with
many diseases, such as Alzheimer's disease, Parkinson's disease and type-2 diabetes …
many diseases, such as Alzheimer's disease, Parkinson's disease and type-2 diabetes …
Spatiotemporal modulations in heterotypic condensates of prion and α-synuclein control phase transitions and amyloid conversion
Biomolecular condensation via liquid-liquid phase separation of proteins and nucleic acids
is associated with a range of critical cellular functions and neurodegenerative diseases …
is associated with a range of critical cellular functions and neurodegenerative diseases …
The multiple functions of PrPC in physiological, cancer, and neurodegenerative contexts
I Grimaldi, FS Leser, JM Janeiro, BG da Rosa… - Journal of Molecular …, 2022 - Springer
Cellular prion protein (PrPC) is a highly conserved glycoprotein, present both anchored in
the cell membrane and soluble in the extracellular medium. It has a diversity of ligands and …
the cell membrane and soluble in the extracellular medium. It has a diversity of ligands and …
Kaempferol has potent protective and antifibrillogenic effects for α-synuclein neurotoxicity in vitro
M Inden, A Takagi, H Kitai, T Ito, H Kurita… - International Journal of …, 2021 - mdpi.com
Aggregation of α-synuclein (α-Syn) is implicated in the pathogenesis of Parkinson's disease
(PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Therefore, the …
(PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Therefore, the …
Understanding Creutzfeldt-Jackob disease from a viewpoint of amyloidogenic evolvability
M Hashimoto, G Ho, Y Takamatsu, R Wada, S Sugama… - Prion, 2020 - Taylor & Francis
ABSTRACT Creutzfeldt-Jackob disease (CJD), the most common human prion disorder, is
frequently accompanied by ageing-associated neurodegenerative conditions, such as …
frequently accompanied by ageing-associated neurodegenerative conditions, such as …
Monomeric α-synuclein (αS) inhibits amyloidogenesis of human prion protein (hPrP) by forming a stable αS-hPrP hetero-dimer.
S Yamashita, Y O. Kamatari, R Honda, A Niwa… - Prion, 2021 - Taylor & Francis
Intermolecular interaction between hPrP and αS was investigated using high-speed atomic
force microscopy, dynamic light scattering, and nuclear magnetic resonance. We found that …
force microscopy, dynamic light scattering, and nuclear magnetic resonance. We found that …
[图书][B] Unzipping the Polyglutamine Steric Zipper Using High Throughput Flow Cytometry
TS Kandola - 2021 - search.proquest.com
The transition of soluble proteins into insoluble aggregates underlies many
neurodegenerative disorders. While disorders vary with respect to age of onset, disease …
neurodegenerative disorders. While disorders vary with respect to age of onset, disease …
Studio UV Raman Risonante sulla struttura proteica, sulla fibrillazione e sull'interazione proteina-ligando
M Pachetti - 2021 - arts.units.it
The term “proteinopathy” was coined to indicate a class of disorders related to protein
misfolding such as Alzheimer's (AD) and Parkinson's (PD) diseases. Nowadays, dementias …
misfolding such as Alzheimer's (AD) and Parkinson's (PD) diseases. Nowadays, dementias …
[图书][B] Neuroinflammation and Alpha-Synuclein Oligomer Toxicity in the Pathogenesis of Lewy Body Dementia and Parkinson's Disease
P La Vitola - 2019 - search.proquest.com
Aggregated α-synuclein has emerged as the core constituent of the typical neuronal
inclusions found in Parkinson's disease and Lewy body dementia. Therefore, huge efforts …
inclusions found in Parkinson's disease and Lewy body dementia. Therefore, huge efforts …