Circulating proteins have important functions in inflammation and a broad range of diseases.
To identify genetic influences on inflammation-related proteins, we conducted a genome …

Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …

Proteome-wide Mendelian randomization (MR) shows value in prioritizing drug targets in
Europeans but with limited evidence in other ancestries. Here, we present a multi-ancestry …

Genome-wide association studies (GWAS) have mapped thousands of susceptibility loci
associated with immune-mediated diseases. To assess the extent of the genetic sharing …

Cognitive decline is a major health concern and identification of genes that may serve as
drug targets to slow decline is important to adequately support an aging population. Whilst …

Decline in cognitive function is the most feared aspect of ageing. Poorer midlife cognitive
function is associated with increased dementia and stroke risk. The mechanisms underlying …

Background Tumour-promoting inflammation is a" hallmark" of cancer and conventional
epidemiological studies have reported links between various inflammatory markers and …

Motivation Colocalization analysis is commonly used to assess whether two or more traits
share the same genetic signals identified in genome-wide association studies (GWAS), and …

Introduction Compared with the traditional drug development pathway, investigating
alternative uses for existing drugs (ie, drug repurposing) requires substantially less time …

Introduction Compared with the traditional drug development pathway, investigating
alternative uses for existing drugs (ie, drug repurposing) requires substantially less time …