Toward understanding Machado–Joseph disease
M do Carmo Costa, HL Paulson - Progress in neurobiology, 2012 - Elsevier
Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is
the most common inherited spinocerebellar ataxia and one of many polyglutamine …
the most common inherited spinocerebellar ataxia and one of many polyglutamine …
Protein aggregation: mechanisms and functional consequences
Understanding the mechanisms underlying protein misfolding and aggregation has become
a central issue in biology and medicine. Compelling evidence show that the formation of …
a central issue in biology and medicine. Compelling evidence show that the formation of …
Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery
L Pascucci, V Coccè, A Bonomi, D Ami… - Journal of controlled …, 2014 - Elsevier
Mesenchymal stromal cells (MSCs) have been proposed for delivering anticancer agents
because of their ability to home in on tumor microenvironment. We found that MSCs can …
because of their ability to home in on tumor microenvironment. We found that MSCs can …
[HTML][HTML] Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation
Amyloids are insoluble protein fibrillar aggregates. The importance of characterizing their
aggregation has steadily increased because of their link to human diseases and material …
aggregation has steadily increased because of their link to human diseases and material …
Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments
The 17-amino-acid N-terminal segment (httNT) that leads into the polyglutamine (polyQ)
segment in the Huntington's disease protein huntingtin (htt) dramatically increases …
segment in the Huntington's disease protein huntingtin (htt) dramatically increases …
Molecular interaction between the chaperone Hsc70 and the N-terminal flank of huntingtin exon 1 modulates aggregation
E Monsellier, V Redeker, G Ruiz-Arlandis… - Journal of Biological …, 2015 - ASBMB
The aggregation of polyglutamine (polyQ)-containing proteins is at the origin of nine
neurodegenerative diseases. Molecular chaperones prevent the aggregation of polyQ …
neurodegenerative diseases. Molecular chaperones prevent the aggregation of polyQ …
Wheat gliadin/xanthan gum intermolecular complexes: Interaction mechanism and structural characterization
M Avadanei, CE Brunchi - Food Chemistry, 2024 - Elsevier
In this study, the interactions between wheat gliadin (GL) and xanthan gum (XG) were
investigated to design new systems with potential applications as a gluten-free substitute …
investigated to design new systems with potential applications as a gluten-free substitute …
Insights into the aggregation mechanism of PolyQ proteins with different glutamine repeat lengths
T Yushchenko, E Deuerling, K Hauser - Biophysical journal, 2018 - cell.com
Polyglutamine (polyQ) diseases, including Huntington's disease, result from the aggregation
of an abnormally expanded polyQ repeat in the affected protein. The length of the polyQ …
of an abnormally expanded polyQ repeat in the affected protein. The length of the polyQ …
The hydrogen-bonding ability of the amino acid glutamine revealed by neutron diffraction experiments
Hydrogen bonding between glutamine residues has been identified as playing an important
role in the intermolecular association and aggregation of proteins. To establish the …
role in the intermolecular association and aggregation of proteins. To establish the …
Monomeric, oligomeric and polymeric proteins in huntington disease and other diseases of polyglutamine expansion
G Hoffner, P Djian - Brain sciences, 2014 - mdpi.com
Huntington disease and other diseases of polyglutamine expansion are each caused by a
different protein bearing an excessively long polyglutamine sequence and are associated …
different protein bearing an excessively long polyglutamine sequence and are associated …